n -乙酰半胱氨酸在预防造影剂诱导的急性肾损伤中的作用:一项随机对照临床试验的系统回顾和meta分析

IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
E. Mezhonov, Y. A. Vyalkina, S. Shalaev
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引用次数: 0

摘要

的目标。分析目前已发表的随机对照临床试验,评估n -乙酰半胱氨酸对造影剂诱导的急性肾损伤(CI-AKI)发生率的影响。材料和方法。根据PRISMA指南对PubMed/MEDLINE数据库中2015年至2022年2月16日期间的现有文献进行检索,进行meta分析。关键词包括MeSH术语“急性肾损伤”或“造影剂肾病”或“AKI”或“CIN”、“造影剂”和“n -乙酰半胱氨酸”。使用RoB 2工具评估研究偏倚。结果:根据最初选择的统计数据进行检索,共发现98篇文献,其中部分文献因不符合meta分析的纳入标准而被排除在分析之外,最终选择了7篇未使用检测源的研究,发现的患者总数为10394例。meta分析结果显示,接受n -乙酰半胱氨酸治疗的CI-AKI患者与未接受n -乙酰半胱氨酸治疗的患者发生aki的频率相同(优势比1.06,95%可信区间0.911.23,p=0.46)。与使用生理盐水(碳酸氢钠或0.9%氯化钠)或安慰剂相比,使用n -半胱氨酸在降低CI-AKI发生率方面没有任何优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
N-acetylcysteine in the Prevention of Contrast-induced Acute Kidney Injury: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials
Aim. To analyze the currently available published randomized controlled clinical trials to evaluate the effect of N-acetylcysteine on the incidence of contrast-induced acute kidney injury (CI-AKI).Material and methods. The meta-analysis was performed in accordance with the PRISMA guidelines based on a search of existing literature in the PubMed/MEDLINE database for the period from 2015 to 16 February 2022. Keywords included MeSH terms «acute kidney injury» or «contrast-induced nephropathy» or «AKI» or «CIN» and «contrast media» and «N-acetylcysteine». The RoB 2 tool was used to assess study bias.Results: When searching based on the initially selected statistics, 98 publications were identified, some of them were excluded from the analysis due to non-compliance with the inclusion criteria in this meta-analysis, 7 studies of unused sources of detection were ultimately selected, the total number of patients in the discovery was 10394.The results of the meta-analysis revealed that in patients treated with N-acetylcysteine CI-AKI developed with the same frequency as in patients who did not observe such therapy as a prophylaxis for this disease (odds ratio 1.06, 95% confidence interval 0.911.23, p=0.46).Conclusion. The use of N-acytelcysteine does not offer any advantage in reducing the incidence of CI-AKI compared with the administration of saline solutions (sodium bicarbonate or sodium chloride 0.9%) or placebo.
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来源期刊
Rational Pharmacotherapy in Cardiology
Rational Pharmacotherapy in Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
1.00
自引率
50.00%
发文量
79
审稿时长
6 weeks
期刊介绍: The primary goals of the Journal are consolidation of information on scientific and practical achievements in pharmacotherapy and prevention of cardiovascular diseases and continuing education of cardiologists and internists. The scientific concept of the edition suggests the publication of information on current achievements in cardiology, the results of national and international clinical trials. The Journal publishes original articles on the results of clinical trials designed to study the effectiveness and safety of drugs, analysis of clinical practice and its compliance with national and international recommendations, expert s’ opinions on a wide range of cardiology issues, associated conditions and clinical pharmacology. There is a heading “Preventive cardiology and public health” in the Journal to stimulate research interest in this highly demanded area. Memories of the outstanding people in medicine including cardiology, which are of great interest to historians of medicine, are published in "Our Mentors” heading.
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