注意缺陷多动障碍患儿血清维生素D与铁蛋白水平关系的研究

Ashima Mehta, B. P. Kalra, Malini Srivastava
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摘要

背景:注意缺陷多动障碍(ADHD)是印度学龄儿童中最普遍的心理健康障碍之一。发病机制归因于多巴胺调节异常,受遗传(编码多巴胺- drd4、DRD5和DAT1的基因)和环境因素的影响。微量营养素如铁和维生素D在神经功能、神经递质合成和调节中起着重要作用。目的:本研究的目的是研究ADHD儿童血清维生素D和血清铁蛋白水平之间的关系。材料与方法:本病例对照研究于2019年10月至2021年5月在某三级医院门诊部进行。研究对象(n=30)包括诊断为ADHD的患者(使用儿童行为检查表和INDT-ADHD)。选取同龄健康儿童作为对照。使用Statistical Package for Social Sciences软件版本22进行统计分析。结果:患者血清铁蛋白水平平均值为32.55±31.97 ng/ml,对照组为143.43±260.40 ng/ml。研究发现,在病例和对照组中,血清铁蛋白水平的平均值有显著差异(p?0.024)。病例组和对照组血清维生素D平均值无显著差异(p-0.229)。结论:低水平的血清铁蛋白与ADHD之间存在关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of the relationship of serum Vitamin D and ferritin levels in children with attention deficit hyperactivity disorder
Background: Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent mental health disorders among school-age children in India. Etiopathogenesis is attributed to abnormal dopamine regulation which is influenced by both genetic (genes encodingdopamine-DRD4, DRD5, and DAT1) and environmental factors. Micronutrients such as iron and Vitamin D play imperative roles in neurologic function, neurotransmitter synthesis, and regulation. Aim: The aim of the study was to study the association between Serum Vitamin D and Serum Ferritin levels in children with ADHD. Materials and Methods: This case–control study was conducted in the outpatient department of a tertiary care hospital, from October 2019 to May 2021. Subjects (n=30) included patients with the diagnosis of ADHD (using child behavior checklist and INDT–ADHD). Healthy children of the comparable age group were taken as controls. Statistical analysis was performed using Statistical Package for the Social Sciences software version 22. Results: The mean value of serum ferritin levels in cases was observed to be 32.55±31.97 ng/ml and in controls was 143.43±260.40 ng/ml. The study found a significant difference in the mean value of serum ferritin levels in cases and controls (p?0.024). No significant difference in the mean value of serum Vitamin D in cases and controls (p–0.229) was noted. Conclusions: An association between low levels of serum ferritin and ADHD was seen. 
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