光敏剂氯e6二甲醚对大鼠M-1型肉瘤光动力治疗的效果

O. Abramova, M. Kaplan, V. Yuzhakov, V. V. Drozhzhina, T. P. Churikova, E. A. Kozlovtseva, L. N. Bandurko, N. D. Yakovleva, L. Sevankaeva, M. G. Tsyganova, S. A. Ivanov, A. Kaprin
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引用次数: 1

摘要

光动力疗法(PDT)是一种局部形式的治疗完全根除实体恶性肿瘤(PDT)。在这项工作中,我们研究了光敏剂(PS)氯e6二甲醚(DME Che6) PDT治疗突变型p53基因阳性肉瘤M-1的效率。为了确定激光照射肿瘤的最佳时间,研究了肿瘤和周围健康组织中PS积累的动力学。采用以下标准评估肿瘤对PDT的反应:肿瘤生长抑制指数(%);肿瘤完全消退(%);绝对生长率(K)指数,用于治疗后肿瘤生长的大鼠;治疗组和荷瘤大鼠对照组的预期寿命增加;治疗反应标准-是指治疗后90天内无肿瘤复发迹象。治疗后第21天,通过观察激光照射区域和组织学分析资料,评估PDT对肿瘤细胞活化的效果。本研究结果表明,DME Che6在治疗M-1肉瘤中具有较高的抗肿瘤活性。如果敏化剂引入和激光照射开始之间的时间最佳,则PS对PDT后恶性肿瘤的抑制作用最大。PDT后对材料进行病理形态学评估,未检测到表达突变p53蛋白的存活肿瘤细胞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficiency of photosensitizer chlorin e6 dimethyl ether for photodynamic therapy of rat sarcoma M-1
Photodynamic therapy (PDT) is a local form of treatment for the complete eradication of solid malignant neoplasms (PDT). In this work, we studied the efficiency of PDT with the photosensi-tizer (PS) chlorin e6 dimethyl ether (DME Che6) in the treatment of positive for the mutant p53 gene sarcoma M-1. To assess the optimal time for tumor irradiation with laser the kinetics of PS accumulation in tumor and surrounding healthy tissues was studied. The tumor response to PDT was assessed with the use of the following criteria: tumor growth inhibition index (%); tumor complete regression (%); absolute growth rate (K) index, it is used in rats with tumor growth after the treatment; increase in the life expectancy in group of treated animals and the control group of tumor-bearing rats; the treatment response criterion – means the absence of signs of tumor re-currence within 90 days after therapy. On the 21st day after the treatment the PDT efficiency for tumor cells devitalization was assessed by examining the areas exposed to laser radiation and data of histological analysis. Results of the study allow us to state that DME Che6 has a high anti-tumor activity in the treatment of M-1 sarcoma. The maximum inhibitory effect of the PS on ma-lignant neoplasms after PDT is achieved if time between the sensitizer introduction and the laser irradiation beginning is optimal. As a result of pathomorphological assessment of material after PDT, no survived tumor cells with expression of the mutant p53 protein were detected.
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