红曲米提取物及其在乳膏制剂中的抗氧化活性试验及其在家兔体内的渗透和安全性试验

J. M. Peranginangin
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引用次数: 1

摘要

红曲米是一种含有黄酮类化合物的食物,黄酮类化合物是一种有用的天然抗氧化剂。克服皱纹的一种方法是使用抗氧化剂。使用红曲米的简单方法是在奶油制剂中配制提取物。本研究旨在测定红曲米提取物及其乳膏剂型的抗氧化活性,并进行渗透性和安全性试验。以96%的乙醇为溶剂,采用发酵法得到红曲米提取物。乳膏采用3种配方制作,其中第一种配方为阴性对照,第二种配方为红曲米提取物乳膏,第三种配方为红曲米微乳液乳膏。DPPH法测定其抗氧化活性,Franz扩散法测定其穿透力,眼部刺激试验测定其安全性。研究结果表明,红曲米提取物具有抗氧化活性,IC50值为2,60 ppm < 50 ppm(强抗氧化),微乳膏的渗透强度大于红曲米提取物膏。初级刺激试验结果表明,乳霜的刺激作用很小,眼部刺激试验结果表明,乳霜对眼睛没有刺激作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ANTIOXIDANT ACTIVITY TEST OF THE RED YEAST RICE EXTRACT AND THE FORMULATION IN A CREAM PREPARATIONS ANDIT’S PENETRATION AND SAFETY TEST AT RABBIT
Red yeast rice is one of thefoodstuff that contains flavonoid compounds which are useful as natural antioxidants. One attempt to overcome wrinkles is with antioxidants. The easy way to apply red yeast rice can be make in an extract that are formulated in cream preparations. This study aims to determine the antioxidant activities of Red yeast rice extract and its formulation in cream dosage form and the test of penetration and safety. Red yeast rice extract obtained by the method of maseration using ethanol 96% as a solvent. The cream is make in 3 formula, where the first formula as a negative control, second formula is cream of red yeast rice extract and third formula is cream of red yeast ricemicroemulsion. The antioxidant activity tested by DPPH method, the penetrationstrengthtested by Franz difussionmethod and the safety by primary and ocular irritation test.Research results demonstrated that red yeast rice extract had activity as antioxidant with the IC50 value was 2,60 ppm < 50 ppm (strong antioxidant)  and microemulsion cream had penetrationstrength greater than red yeast rice extractcream. And the results of the primary irritation test showed that the cream is very little irritate and the results of the ocular irritation test cream does not irritate the eyes.
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