S. Ōmura, Haruo Tanaka, J. Awaya, Y. Narimatsu, Yaeko onda, T. Hata
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引用次数: 1
摘要
在我们对链霉菌菌株生物碱产量的检测过程中，发现链霉菌sp. NA-15在培养基中产生一种新的生物碱pyrindin。菌株NA-15为灰黄链霉菌(Streptomyces griseoflavus var. pyr indie us nov. var)的一种变异菌株，对产pyrindintin的培养条件进行了研究，得到了产pyrindinin的盐化物(mp 145℃，分解)。该化合物具有较弱的抗菌活性和多种药理活性。盐酸(ip，小鼠)的LD50为87 mg/kg。
Pyrindicin, a New Alkaloid from a Streptomyces Strain
In the course of our examination for the alkaloid productivities of Streptomyces strains, Streptomyces sp. NA–15 was found to produce a new alkaloid, pyrindicin, in the culture medium. The strain NA–15 was found to be a variant of Streptomyces griseoflavus and was designated as S. griseoflavus var. pyr indie us nov. var.After the culture conditions for pyrindicin production were studied, pyrindicin was obtained as its hydrochloride (mp 145°C, decomp.) from the cultured broth. The compound was shown to possess weak antimicrobial and several pharmacological activities. The LD50 of the hydrochloride (ip, in mice) was 87 mg/kg.
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