串联质谱法在临床实验室:教程概述

IF 2.1 Q4 Chemistry

Clinical Mass Spectrometry Pub Date : 2020-01-01 DOI:10.1016/j.clinms.2019.09.002

J. Grace van der Gugten

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引用次数: 16

摘要

串联质谱法(串联质谱)是一种基于分子质量直接测量化合物的强大技术。液相色谱三重四极杆质谱法(LC-MS/MS)是串联质谱法的一种，近年来越来越多地被临床实验室采用。虽然它是复杂和具有挑战性的，但它具有选择性和准确性优于更传统的实验室技术，如免疫测定。LC-MS/MS能够测量范围广泛的化合物，当正确使用和实施时，LC-MS/MS可以使临床实验室受益并改善患者护理。这篇迷你综述是对临床LC-MS/MS新手用户的介绍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tandem mass spectrometry in the clinical laboratory: A tutorial overview

Tandem mass spectrometry (tandem MS) is a powerful technique that directly measures compounds based on their molecular weight. Liquid chromatography triple quadrupole mass spectrometry (LC-MS/MS), a type of tandem MS, has been increasingly adopted by clinical laboratories in recent years. While it is complicated and challenging, it has selectivity and accuracy advantages over more traditional laboratory techniques such as immunoassay. Able to measure a wide range of compounds, when correctly utilized and implemented, LC-MS/MS can benefit the clinical laboratory and improve patient care. This mini review is an introduction to clinical LC-MS/MS for the novice user.

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来源期刊

Clinical Mass Spectrometry Chemistry-Spectroscopy

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Clinical Mass Spectrometry publishes peer-reviewed articles addressing the application of mass spectrometric technologies in Laboratory Medicine and Clinical Pathology with the focus on diagnostic applications. It is the first journal dedicated specifically to the application of mass spectrometry and related techniques in the context of diagnostic procedures in medicine. The journal has an interdisciplinary approach aiming to link clinical, biochemical and technological issues and results.