大鼠单次和多次给药的利尿作用

Sarah Khan, S. Afroz, R. Khan
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引用次数: 2

摘要

利尿剂被有效地用于管理各种临床紧急情况,如高血压、心力衰竭、肝硬化、高钙尿、血尿和肾病综合征。Cymbopogon jwarancusa是一种芳香的多年生草,用于传统和Unani医学系统,以根除感冒、季节性发烧、哮喘、肺结核、风湿痛、背痛、牙痛和神经紊乱等疾病。C. jwarancusa精油用于香水、肥皂、洗涤剂、药品和制药工业。单萜类和倍半萜类是金莲精油中含量最高的成分。本实验旨在比较单次和多次给药后的利尿活性。以速尿(20 mg/kg)为对照药,10% DMSO为对照药。通过测量尿量和计算利尿和利普奇茨值来观察利尿活性。单次和多次给药后,500 mg/kg提取物的利尿作用最大。根据上述结果,可以认为黄刺草可作为利尿剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diuretic Effect of Cymbopogon jwarancusa after Single and Multiple Doses in Rats
Diuretics are efficaciously used in management of various clinical emergencies like hypertension, heart failure, cirrhosis, hypercalciuria, hematuria and nephrotic syndrome. Cymbopogon jwarancusa is an aromatic perennial grass used in both traditional and Unani system of medicine to eradicate diseases like colds, seasonal fever, asthma, tuberculosis, rheumatic pain, back pain, toothache and nervous disorders. C. jwarancusa essential oils are used in perfumery, soap, detergents, medicines and pharmaceutical industry. Monoterpenes and sesquiterpenes constitute the highest composition in essential oil of C. jwarancusa. The present was designed to compare the diuretic activity of C. jwarancusa after single and multi-doses. Furosemide (20 mg/kg) was used as reference drug and 10% DMSO was used as vehicle. Diuretic activity was noticed by measuring urine volume and calculating diuretic and Lipchitz values. Maximum diuretic response was observed at 500 mg/kg of extract after both single and multi-dose administration. On basis of results it may be concluded that C. jwarancusa may be used as diuretic agent.
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