维生素E和Omega-3对阿霉素诱导小鼠肝毒性的保护作用

IF 0.4 Q4 ONCOLOGY
A. Lotfi, Siamak Mashhady Rafie, S. Hesaraki, K. Amini
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引用次数: 0

摘要

背景:阿霉素是治疗多种恶性肿瘤的常用药物。所有器官的肝毒性作用都是破坏性的,请谨慎使用。因此,有必要在服用阿霉素的同时增加抗氧化剂,以降低其毒性。维生素E是一种有害的抗氧化剂。Omega-3也是一种抗氧化剂。研究了维生素E- Omega-3对阿霉素的愈合能力。方法:30只体重为25 g的balb/c小鼠分成5组,每组6只。对照组:生理盐水组;阿霉素:阿霉素;维生素E:维生素E + DOX;欧米伽- 3;Omega-3 + DOX;两种维生素E- Omega-3 + DOX。组织病理学描述了空泡变性、炎症和坏死。免疫组化检测肿瘤坏死因子(TNFα)表达,显示炎症。结果:与维生素E和omega-3共同给药时,dox诱导的肝损伤和TNF-α表达增加比单独给药时更多。与对照组相比,ALT、AST、GGT和ALP水平显著降低。同时服用维生素E- 3组的谷胱甘肽过氧化物酶和过氧化氢酶活性高于服用维生素E或Omega-3组。结论:维生素E和Omega-3联合给药对阿霉素引起的肝毒性具有更强的修复能力和控制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective Effects of Coadministration of the Vitamin E and Omega-3 on Doxorubicin-Induced Hepatotoxicity in Mice
Background: Doxorubicin is a favorite drug for feasting many malignancies. All organs' hepatic toxic effects are destructive and lead to use with caution. Then, it is necessary to increase antioxidants accompanied with doxorubicin to reduce its toxicity. Vitamin E is an antioxidant with harmful consequences. Omega-3 is an antioxidant similarly. The healing capacity of Vitamin E- Omega-3 was investigated together against doxorubicin. Methods: Thirty balb/c mice have divided a weight of 25 g into five equal groups of six mice each. The groups were classified as Control: normal saline; DOX: Doxorubicin; Vitamin E: Vitamin E + DOX; Omega-3; Omega-3 + DOX; Both Vitamin E- Omega-3 + DOX. The histopathology was set to describe vacuolar degeneration, inflammation, and necrosis. Immunohistochemistry was performed to estimate the expression of tumor necrosis factor (TNFα), demonstrating the inflammation. Results: DOX-induced hepatic injury and increased TNF-α expression were seen more than alone when co-administered with vitamin E and omega-3. A significant decrease was shown in the ALT, AST, GGT, and ALP levels compared to the control. The Glutathione peroxidase and Catalase enzyme activities were higher in the co-administered Vitamin E- Omega-3 group than that received Vit E or Omega-3. Conclusions: Co-administration of Vitamin E and Omega-3 have a more repair capacity with controlling effects on Doxorubicin-induced liver toxicity.
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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