胫骨分离性髓系肉瘤

M. Serrado, A. L. Proença, P. Alves
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引用次数: 0

摘要

髓样肉瘤是一种罕见的髓外未成熟髓样细胞肿瘤,可在身体任何部位发现。它可能先于或同时发生于急性髓性白血病、慢性髓性白血病或骨髓增生性疾病/骨髓增生异常综合征。本文报告一例罕见的儿童右胫骨髓样肉瘤,诊断时无白血病累及。诊断具有挑战性,需要多种成像方式(x线摄影,计算机断层扫描,磁共振,骨显像,正电子发射断层扫描-计算机断层扫描)。此外,为了做出明确和结论性的诊断,需要进行三次活检。通过这一病例报告,作者想强调在儿童溶解性骨病变的鉴别诊断中考虑髓系肉瘤的必要性,并强调在没有白血病证据的情况下需要高度的临床怀疑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolated myeloid sarcoma of the tibia
Myeloid sarcoma is a rare tumor of immature myeloid cells in an extramedullary site which can be found in any part of the body. It may precede or concurrently occur with acute myeloid leukemia, chronic myeloid leukemia, or myeloproliferative disorders/myelodysplastic syndrome.Herein is reported the rare case of a child with myeloid sarcoma in the right tibia, without leukemic involvement at diagnosis. Diagnosis was challenging and several imaging modalities (radiography, computed tomography, magnetic resonance, bone scintigraphy, positron emitted tomography–computed tomography) were required. Additionally, three biopsies were necessary to make a definitive and conclusive diagnosis.With this case report, the authors intend to emphasize the need of considering myeloid sarcoma in the differential diagnosis of lytic bone lesions in children and highlight the high degree of clinical suspicion required when there is no leukemia evidence.
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