Y. Basok, A. A. Kondratenko, L. Kalyuzhnaya, E. Volkova, K. Vorobyov, V. Sevastianov
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The review critically analyzes and summarizes published data on the ability of decellularized UC stroma to maintain the necessary conditions for adhesion, migration, differentiation and functional activity of adherent cells, thus stimulating the internal (physiological) regenerative potential of tissues. Literature was searched for in the following electronic databases: Medline/PubMed (www/ncbi. nlm.nih.gov/pubmed), Cochrane library (https://www.cochrane.org), and eLIBRARY/Russian Science Citation Index (https://www.elibrary.ru). Inclusion criteria were the presence of biomaterials obtained from decellularized human UC stroma. Exclusion criteria for papers included research objects as decellularized umbilical cord vessels (veins and arteries) and umbilical cord cell cultures. Twenty-five original articles in English and Russian were selected for analysis of the products obtained, their applications, decellularization methods and research results. 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引用次数: 0
摘要
尽管用于组织工程和再生医学的生物材料领域取得了很大进展,但对人工基质(基质、载体、支架)的高要求是不断寻找天然或合成细胞外基质模拟物的原因。在这些材料中,脱细胞脐带(UC)基质似乎非常有吸引力-它具有高含量的透明质酸,细胞因子和生长因子,并且对其生产没有伦理限制。脱细胞UC基质已被发现促进软骨、肝组织和神经组织修复,以及伤口愈合。这篇综述批判性地分析和总结了关于脱细胞UC间质维持贴壁细胞粘附、迁移、分化和功能活性的必要条件,从而刺激组织内部(生理)再生潜力的已发表数据。在以下电子数据库中检索文献:Medline/PubMed (www.ncbi)。nlm.nih.gov/pubmed)、Cochrane图书馆(https://www.cochrane.org)和eLIBRARY/Russian Science Citation Index (https://www.elibrary.ru)。纳入标准是存在从脱细胞人UC基质中获得的生物材料。论文的排除标准包括研究对象为脱细胞脐带血管(静脉和动脉)和脐带细胞培养物。选取25篇英文和俄文的原创文章,对所获得的产品、应用、脱细胞方法和研究结果进行分析。并对脱细胞脐带在医学上的应用前景进行了展望。
Decellularized umbilical cord stroma in tissue engineering and regenerative medicine: a systematic review
Despite great progress in the field of biomaterials for tissue engineering and regenerative medicine, the high requirements placed on artificial matrices (matrices, carriers, scaffolds) are the reason for the ongoing search for natural or synthetic extracellular matrix mimetics. Among such materials, decellularized umbilical cord (UC) stroma appears to be very attractive – it has a high content of hyaluronic acid, cytokines, and growth factors, and there are no ethical restrictions for its production. Decellularized UC stroma has been found to promote cartilage, liver tissue and nerve tissue repair, as well as wound healing. The review critically analyzes and summarizes published data on the ability of decellularized UC stroma to maintain the necessary conditions for adhesion, migration, differentiation and functional activity of adherent cells, thus stimulating the internal (physiological) regenerative potential of tissues. Literature was searched for in the following electronic databases: Medline/PubMed (www/ncbi. nlm.nih.gov/pubmed), Cochrane library (https://www.cochrane.org), and eLIBRARY/Russian Science Citation Index (https://www.elibrary.ru). Inclusion criteria were the presence of biomaterials obtained from decellularized human UC stroma. Exclusion criteria for papers included research objects as decellularized umbilical cord vessels (veins and arteries) and umbilical cord cell cultures. Twenty-five original articles in English and Russian were selected for analysis of the products obtained, their applications, decellularization methods and research results. The review also discusses the prospects for decellularized umbilical cord in medicine.