Proto-oncogenes Crosstalk, Feedback and Expression, and Anticancer Drugs Resistance

Proto-oncogenes like C-MYC, EGFR and others have physiological function in regeneration, wound and any stressfully injury to maintain tissue echotexture and healing. Notably, these growth factors work together and had life span to retain to basal level after tissue remodeling and retain its function like what happen in partial hepatectomy. While in cancer, as we work out in 2 transgenic model of liver cancer, we notice that oncogenes do not like each other and just one of them was highly expressive, it keeps other ones at basal level or degraded. Moreover, if one oncogene was inhibited or silenced, other oncogenes become active or expressed and result in anticancer drug resistance. So bispecific antibody could successfully reduce anti-cancer drug resistance.