Study of serum sodium and serum potassium level in chronic renal failure

C.R.F. Chronic renal failure is a progressive loss in renal function over a period of months or years. It is a long term condition caused by damage to both kidneys. There is no single cause and damage is usually irreversible and can lead to ill health. It is associated with significant morbidity and mortality. Methods : The present study included 30 chronic renal failure patients of both sexes and 30 healthy controls of both sexes. Special care were taken to ensure that females were neither on contraceptive pills and nor pregnant. Result: The comparison of serum sodium and serum potassium levels between control cases and CRF cases were found to be statically significant (p<.005). Conclusion: Serum sodium level decrease and serum potassium level were found elevated in CRF cases as compare to control cases. Summary: In renal disease with CRF shows low serum sodium level and high serum potassium level as compare to control. This is due to malfunctioning of aldosterone and rennin–angiotensin system, glomerular filtration and decreased reabsorption. So these patients sometime need replacement therapy.