İ. Kılıç, Elif Tuğba Oğuz Taylan, İ. Kurultak, S. Üstündağ
{"title":"慢性肾脏疾病的炎症标志物c反应蛋白和平均血小板体积","authors":"İ. Kılıç, Elif Tuğba Oğuz Taylan, İ. Kurultak, S. Üstündağ","doi":"10.32598/jid.26.4.1","DOIUrl":null,"url":null,"abstract":"Background: People with chronic kidney disease (CKD) experience chronic systemic inflammation. Although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. As inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. Here, we report the relation of C-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients. Methods: This study was an observational retrospective single-center study conducted on the record of CKD patients to detect the outcomes over a median follow-up time of three years. Demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. We investigated the multivariable association of plasma levels of C-reactive protein and mean platelet volume with the progression of CKD in the study participants. Findings: Elevated plasma levels of C-reactive protein (r=0.13, P<0.001) and mean platelet volume (r=0.23, P<0.001) were associated with a greater loss of kidney function over time. The presence of diabetes mellitus was detected to be a risk factor for CKD progression (P=0.04). An inverse relationship was detected between sodium and creatinine (P<0.001). In addition, a weak association was detected between uric acid and creatinine (P<0.001). Conclusion: Elevated plasma levels of C-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with CKD.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease\",\"authors\":\"İ. Kılıç, Elif Tuğba Oğuz Taylan, İ. Kurultak, S. Üstündağ\",\"doi\":\"10.32598/jid.26.4.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: People with chronic kidney disease (CKD) experience chronic systemic inflammation. Although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. As inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. Here, we report the relation of C-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients. Methods: This study was an observational retrospective single-center study conducted on the record of CKD patients to detect the outcomes over a median follow-up time of three years. Demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. We investigated the multivariable association of plasma levels of C-reactive protein and mean platelet volume with the progression of CKD in the study participants. Findings: Elevated plasma levels of C-reactive protein (r=0.13, P<0.001) and mean platelet volume (r=0.23, P<0.001) were associated with a greater loss of kidney function over time. The presence of diabetes mellitus was detected to be a risk factor for CKD progression (P=0.04). An inverse relationship was detected between sodium and creatinine (P<0.001). In addition, a weak association was detected between uric acid and creatinine (P<0.001). Conclusion: Elevated plasma levels of C-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with CKD.\",\"PeriodicalId\":91544,\"journal\":{\"name\":\"Journal of inflammatory bowel diseases & disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of inflammatory bowel diseases & disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32598/jid.26.4.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of inflammatory bowel diseases & disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/jid.26.4.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease
Background: People with chronic kidney disease (CKD) experience chronic systemic inflammation. Although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. As inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. Here, we report the relation of C-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients. Methods: This study was an observational retrospective single-center study conducted on the record of CKD patients to detect the outcomes over a median follow-up time of three years. Demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. We investigated the multivariable association of plasma levels of C-reactive protein and mean platelet volume with the progression of CKD in the study participants. Findings: Elevated plasma levels of C-reactive protein (r=0.13, P<0.001) and mean platelet volume (r=0.23, P<0.001) were associated with a greater loss of kidney function over time. The presence of diabetes mellitus was detected to be a risk factor for CKD progression (P=0.04). An inverse relationship was detected between sodium and creatinine (P<0.001). In addition, a weak association was detected between uric acid and creatinine (P<0.001). Conclusion: Elevated plasma levels of C-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with CKD.