10%艾非那康唑溶液:一种治疗甲真菌病的新型局部抗真菌药物

B. Elewski
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引用次数: 2

摘要

甲真菌病是一种常见的指甲感染,治疗方法有限,10多年来没有引入新的治疗方法。虽然患者可能更喜欢局部治疗,但环匹罗和阿莫罗芬漆的疗效令人失望,特别是在中度至重度疾病中。10%艾非那康唑溶液是一种新型三唑类抗真菌药物,专门用于局部治疗甲癣。它的理化性质,抗真菌活性和配方都是开发计划的重要方面,在这里进行综述。10%艾非那康唑溶液可能提供口服治疗甲癣的第一个可行的替代方案。真菌学治愈率与口服伊曲康唑相当,比环匹罗漆的治愈率更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efinaconazole 10% solution: a new topical antifungal therapy for onychomycosis
Onychomycosis is a common nail infection for which treatment options are limited, and no new treatment have been introduced for over 10 years. While patients might prefer a topical therapy, efficacy with ciclopirox and amorolfine lacquers has been disappointing especially in moderate to severe disease. Efinaconazole 10% solution is a new triazole antifungal, specifically developed for the topical treatment of onychomycosis. Its physicochemical properties, antifungal activity and formulation are all important aspects of the development program and are reviewed here. Efinaconazole 10% solution may provide the first viable alternative to oral therapy for onychomycosis. Mycologic cure rates are comparable to those seen with oral itraconazole, and greater than reported with ciclopirox lacquer.
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