D. R. Patil, Sonali M. Salunkhe, M. Deshmukh, P. Anbhule
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One Step Synthesis of 6-Amino-5-Cyano-4-Phenyl-2-Mercapto Pyrimidine Using Phosphorus Pentoxide
A simple and efficient approach towards one step synthesis of 6-amino-5-cyano-4-phenyl-2-mercapto pyrimidine and its hydroxyl derivatives have been developed by three component condensation of aromatic aldehydes, malononitrile and thiourea/urea in presence of phosphorus pentoxide (Scheme 1).
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