MiR92b 3p在鱼类化学性肝损伤诊断及基于miRNA治疗中的功能研究

P. Brzuzan, M. Woźny, M. Florczyk
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引用次数: 0

摘要

令人惊讶的是,关于微囊藻毒素- lr (MC-LR)引起的不良反应的分子背景知识的持续缺乏。这种毒素需要额外的关注,不仅因为它能够引起急性中毒,而且因为它能够在急性剂量下引发癌症,并可能通过长期接触低浓度的饮用水而促进癌症。我们最近对白鱼(Coregonus lavaretus)的研究表明,长期暴露于MC-LR会导致严重的肝脏损伤,随后会导致肝脏再生和意想不到的对进一步毒素摄取的恢复能力。这些影响伴随着肝脏microrna (mirna)的扰动,其靶基因涉及细胞骨架重塑、细胞代谢、细胞周期调节和细胞凋亡。在最明显的个体改变中,©瓦姆尼亚大学和马佐里在OLSZTYN缩写anti - ir microRNA反义寡核苷酸(抑制剂)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional investigation of MiR92b 3p for diagnosis and miRNA based cure in chemically induced liver injury in fish: a project description
The continued lack of knowledge concerning the molecular background of adverse effects caused by microcystin-LR (MC-LR) is surprising. This toxin requires additional attention, not only for its ability to cause acute poisoning, but also for its ability to initiate cancer in acute doses, and potentially, to promote cancer via chronic exposure to low concentrations in drinking water. Our recent studies on whitefish (Coregonus lavaretus) revealed that long-term exposure to MC-LR resulted in severe liver injury, followed by regeneration of the liver and its unexpected resilience to further toxin uptake. These effects were accompanied by perturbations of hepatic microRNAs (miRNAs) that have target genes involved in cytoskeletal remodeling, cell metabolism, cell cycle regulation, and apoptosis. Among the most pronounced individual alterations, © UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN ABBREVIATIONS antimir microRNA antisense oligonucleotide (inhibitor)
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