从儿童癫痫中心过渡到成人癫痫中心治疗癫痫患者时的药理学考虑

IF 0.2 Q4 PEDIATRICS
Natalie Guido-Estrada, Shifteh Sattar
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引用次数: 0

摘要

在现有文献的回顾中,很少有证据支持癫痫患者从儿科中心到成人中心的护理过渡的明确和优越的模型。有趣的是,人们普遍认为,家庭不愿做出这种改变,癫痫治疗的成功过渡对患者、家庭和医生来说可能是一项挑战。作为使病人和家属为成人护理模式做好准备的努力的一部分,应解决几个治疗问题。在这篇文章中,我们从药理学的角度讨论了医生在治疗癫痫患者的过渡期所面临的具体挑战,包括代谢和药效学的差异,这些差异会影响抗癫痫药物的耐受性或疗效,生活方式的改变会影响药物依从性和癫痫控制,获得性成人健康状况需要使用新的药物,可能导致药物不良反应。成人神经科医生可能对儿童癫痫患者通常使用的某些药物缺乏熟悉。我们提供这作为一个指南,以避免许多可能的陷阱之一,当癫痫患者过渡到成人护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacological Considerations When Transitioning the Care of Epilepsy Patients from Pediatric to Adult Epilepsy Centers
Abstract There is scarce evidence in review of the available literature to support a clear and superior model for the transition of care for epilepsy patients from pediatric to adult centers. Anecdotally, there is a common perception that families are reluctant to make this change and that the successful transition of care for epilepsy can be a challenge for patients, families, and physicians. As part of the effort to prepare the patient and family for the adult model of care, several treatment issues should be addressed. In this article, we discuss the specific challenges for physicians in transition of care for epilepsy patients from a pharmacological standpoint, which include differences in metabolism and pharmacodynamics that can impact tolerability or efficacy of antiepileptic medications, lifestyle changes affecting medication compliance and seizure control, acquired adult health conditions necessitating new medications that may result in adverse drug interactions, and adult neurologists' potential lack of familiarity with certain medications typically used in the pediatric epilepsy population. We offer this as a guide to avoid one of the many possible pitfalls when epilepsy patients transition to adult care.
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来源期刊
自引率
0.00%
发文量
21
期刊介绍: The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.
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