Evaluation of the Novel Herbal Formulation for its Cardioprotective Action against Streptozotocin Induced Diabetes in Rats

Diabetes mellitus is extremely serious condition from both clinical and public health standpoints. Poor people in India do not have access to the resources needed to treat this condition. The recent decade has witnessed many landmark observations, which have added to the scientific credentials of Ayurveda system of India. The research was done to develop the novel herbal formulation with the antidiabetic and hypoglycaemic herbs described in various past research at Ocular Pharmacology lab DIPSAR. Wistar albino rats (150–200 g) of either sex were chosen to actuate Type-1 Diabetes. The animals were divided into three groups; two groups were injected with Streptozotocin (STZ) dissolved in citrate buffer (pH-4.5) at a dose of 45 mg/kg i.p. to induce diabetes. The third group served as normal control group and was injected only with citrate buffer (pH-4.5). Drug treatment was done for sixteen weeks with the Novel herbal formulation. The level of VEGF an TNF-α were further reduced significantly. Above results were further confirmed by histopathological findings. Thus, from the present study it is concluded that Novel herbal formulation may be of therapeutic and prophylactic value in the treatment of cardiomyopathy.