Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl/Benzyl-4-Chlorobenzenesulfonamide Derivatives

In the undertaken research, a number of N-dimethylphenyl substituted derivatives of N-ethyl/benzyl-4-chlorobenzenesulfonamide, (6a-f & 7a-f) was synthesized and also estimated for their biological potential. The reaction of 4-chlorobenzenesulfonyl chloride with different dimethyl substituted phenyl amine (2a-f) in the presence of basic aqueous media yielded N-[(Dimethyl substituted) phenyl]-4-chlorobenzenesulfonamides (3a-f). The targeted compounds 6a-f & 7a-f were synthesized by the reaction of compounds 3a-f with electrophiles, ethyl bromide/benzyl chloride in the presence of base NaH and polar aprotic solvent (DMF). The structures of the compounds were elucidated through H-NMR, IR and mass spectral data. The synthesized compounds (6a-f & 7a-f) were screened against Gram-negative & Gram-positive bacteria and also subjected for enzyme inhibition potential against lipoxygenase and chymotrypsin enzymes and almost all the compounds exhibited moderate to good activities.