胎动减少-首先对胎儿无害

A. Saunders, C. Griffin
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引用次数: 1

摘要

亲爱的编辑,我们怀着极大的兴趣阅读了一份关于胎动减少(DFM)的最有吸引力和实用的临床指南30 - 55%经历过死产的妇女在前一周有DFM这种假定的负面临床事件长期以来被认为是干预的机会。最近发表的AFFIRM研究(2018年11月)是第一个随机试验,涉及409175例妊娠,使用与挪威类似的干预方案(患者在同一环境下对DFM的主观感知),预计将使死产率降低30%AFFIRM研究的结果令支持干预减少胎动的人感到失望。死产率没有统计学上的显著降低,但引产率和剖宫产率以及新生儿在新生儿重症监护室的平均住院时间有所增加此外,干预组新生儿后期死亡率较高。在我们积极防止死产的过程中,我们是否违反了无害原则?另外,正如Walker和Thornton所建议的那样,保留我们目前的方法可能更安全,但要限制对怀孕超过37周的妇女进行宣传活动考虑到AFFIRM研究的阴性或无效结果,当地指南是否应立即补充说明,在等待进一步证据的同时,没有可靠的科学方法来减少胎动?
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reduced fetal movements – First do no harm
Dear Editor, We read with great interest a most engaging and pragmatic clinical guideline for decreased fetal movements (DFM).1 Between 30– 55% of women who experience a stillbirth retrospectively noted DFM in the preceding week.2 This presumed negative clinical incident has long been perceived as opportunity for intervention. The AFFIRM study, recently published (November, 2018), was to be the first randomised trial involving 409 175 pregnancies that used a similar intervention package as in Norway (subjective perception of DFM by a patient in a contemporaneous setting) and was expected to deliver a 30% reduction in the rate of stillbirths.2 The results of the AFFIRM study have been disappointing to the supporters of intervention for reduced fetal movements. There was no statistically significant reduction in the stillbirth rate but rather an increase in induction and caesarean section rates, and average neonatal length of stay in neonatal intensive care.2 Also, in the intervention group there was a higher rate of post neonatal deaths. In our exuberance to prevent stillbirths, have we violated the principle of nonmaleficence? Alternatively, as suggested by Walker and Thornton, it might be safer to retain our current approach but rather place limits on awareness campaigns to gestations greater than 37 weeks.3 Reflecting upon the negative or null findings of the AFFIRM study, should the local guideline have an immediate addendum to clarify that there is no robust scientific approach to reduced fetal movements while awaiting further evidence?
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