硫酸脱氢表雄酮水平与老年人膝关节骨性关节炎:可能联系的初步数据

D. Rasheedy, M. Refaee, Ghada Farag, Samia Abdelrehem, S. Pessar
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引用次数: 0

摘要

背景:脱氢表雄酮(DHEA)被认为对关节软骨损伤有保护作用,被广泛用作炎症性和退行性关节炎的自然疗法之一。然而,关于DHEA水平与膝关节OA之间关系的信息缺乏。目的:探讨老年患者血清硫酸脱氢表雄酮(DHEAs)水平与膝关节炎的关系。方法:对在艾因沙姆斯大学医院门诊就诊的60岁及以上老年患者80例(男40例,女40例)进行病例对照研究。参与者接受了膝关节的标准临床检查,使用WOMAC OA指数评估身体困难和疼痛严重程度。膝关节半屈位的负重正位x线片。检测DHEAs的血清水平。结果:男性膝关节OA患者血清DHEAs水平为0.29±0.17 μg/mL,非膝关节OA患者血清DHEAs水平为0.59±0.51 μg/mL (p=0.006);女性膝关节OA患者血清DHEAs水平为0.25±0.11 μg/mL,非膝关节OA患者血清DHEAs水平为0.39±0.26 μg/mL,差异无统计学意义(p=0.044*)。此外,血清DHEAs水平与男女膝关节OA严重程度呈负相关。结论:血清DHEAs水平和膝关节OA的发生存在性别差异。老年膝关节OA患者DHEAs水平较低,血清DHEAs水平与膝关节OA严重程度呈负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dehydroepiandrosterone sulfate level and knee osteoarthritis in older adults: preliminary data for the possible link
Background: Dehydroepiandrosterone (DHEA) is believed to be protective against articular cartilage injury and it is widely used as one of the natural remedies for inflammatory and degenerative arthritis. Yet, information about the association between DHEA level and knee OA is lacking. Objectives: To explore the link between serum dehydroepiandrosterone sulfate (DHEAs) levels and knee OA among elderly patients. Methods: A case control study was conducted on 80 elderly subjects (40 males, 40 females) aged 60 years and older attending the outpatient clinics in Ain Shams University Hospital. Participants underwent a standard clinical examination of the knee, assessment of physical difficulty and pain severity using WOMAC OA index. Weight-bearing anteroposterior radiographs of the knees in the semi-flexed position were performed. Serum levels of DHEAs were examined. Results: The serum level of DHEAs in males with knee OA was 0.29 ± 0.17 μg/mL compared to those without knee OA 0.59 ± 0.51 μg/mL (p=0.006), small but significant difference existed between the serum level of DHEAs in females with knee OA 0.25 ± 0.11 μg/mL compared to those without knee OA 0.39 ± 0.26 μg/mL (p=0.044*). Additionally, the serum DHEAs level negatively correlated with the severity of knee OA in both sexes. Conclusions: There was a sex difference in serum DHEAs level and occurrence of knee OA. Lower levels of DHEAs were reported in elderly with knee OA and the serum DHEAs level negatively correlated with the severity of knee OA.
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