丙戊酸蛋白结合在ICU患者中是高度可变的，不能由总血清浓度预测:病例系列和文献回顾

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-04-01 DOI:10.1002/phar.1912

R. Riker, David J. Gagnon, C. Hatton, Teresa L. May, David B. Seder, Katie Stokem, G. Fraser

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引用次数: 27

摘要

丙戊酸的游离部分(药理学活性部分，通常为5-10%)在危重患者中可能有显著差异，但这一主题尚未得到充分研究，只有4例重症监护病房(ICU)病例报告。本研究的目的是评估ICU患者丙戊酸血浆蛋白结合的范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Valproate Protein Binding Is Highly Variable in ICU Patients and Not Predicted by Total Serum Concentrations: A Case Series and Literature Review

The free fraction of valproate (the pharmacologically active moiety, normally 5–10%) may vary significantly in critically ill patients, but this topic is understudied, with only four prior intensive care unit (ICU) case reports. The objective of this study was to evaluate the range of valproate plasma protein binding in ICU patients.

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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

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