CMOS微系统上自然神经元组成的生物微电子信息处理装置

TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference Pub Date : 2007-06-10 DOI:10.1109/SENSOR.2007.4300357

S. Hafizovic, F. Heer, U. Frey, T. Ugniwenko, A. Blau, C. Ziegler, A. Hierlemann

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引用次数: 1

摘要

我们报道了一种CMOS芯片的系统集成，该芯片能够与神经元或心肌细胞等致电细胞进行双向通信(刺激和记录)，旨在研究体外细胞网络中的电信号传播。实验包括以两种不同的时空模式刺激神经元和记录触发的尖峰活动。对于不同的刺激模式，神经元的反应模式已经被成功地分类(83%的分类正确)。

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Bio-Microelectronic Information Processing Device Consisting of Natural Neurons on a CMOS Microsystem

We report on the system integration of a CMOS chip that is capable of bidirectionally communicating (stimulation and recording) with electrogenic cells such as neurons or cardiomyocytes, and that is targeted at investigating electrical signal propagation within cellular networks in vitro. Experiments including the stimulation of neurons with two different spatio-temporal patterns and the recording of the triggered spiking activity have been carried out. The neuronal response patterns have been successfully classified (83% correct classifications) with respect to the different stimulation patterns.

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TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference

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