膳食姜黄素对小鼠肝肾alfla中毒的影响

H. Abdelrazek, D. Zeidan, M. Soliman, Alaa Kh. A. Khodry
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引用次数: 1

摘要

真菌毒素造成严重的不良健康问题,特别是对肝脏和肾脏。本研究旨在探讨姜黄素对小鼠肝肾黄曲霉中毒的保护作用。雄性白化小鼠32只,18 ~ 20 g,随机分为4组。第一组,为对照组,饲喂基础日粮。第二组,基础饲粮中添加2%姜黄素。第三组,在基础饲粮中添加AFs(5µg/kg)。第四组,以相同的先前剂量同时给药AFs和姜黄素。所有治疗均持续4周。测定肝脏和肾脏重量以及食物转化率(FCR)。测定血清超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、丙二醛(MDA)和白细胞介素-6 (IL-6)水平。测定血清丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、白蛋白和肌酐。行肝、肾组织病理学检查。与对照组相比,AFs显著提高了FCR和肝脏重量。III组SOD和TAC水平显著降低,MDA和IL-6水平较对照组升高。AFs组AST、ALT、肌酐水平显著升高(P<0.05),白蛋白水平显著降低(P<0.05)。肝、肾组织充血、淋巴细胞浸润等退行性改变。姜黄素与AFs联合使用可显著改善AFs引起的不良反应。姜黄素具有抗氧化作用,可改善黄曲霉中毒对肾脏和肝脏的不良影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Dietary Curcumin on Heptorenal Alfla-Toxicosis in Mice
Mycotoxins contribute great adverse health concerns, especially on liver and kidney. The current study aimed to investigate the possible protective effect of dietary curcumin on hepatorenal aflatoxicosis in mice. Thirty-two male albino mice 18-20 g were divided into 4 groups. Group I, is the control group received basal diet. Group II, received a basal diet with 2% curcumin.  Group III, given a basal diet with added AFs (5 µg/kg). Group IV, co-administered AFs and curcumin at the same previous doses. All treatments continued for 4 weeks. Liver and kidney weights, as well as food conversion ratio (FCR), were determined. The serum levels of Superoxide dismutase (SOD), total antioxidant capacity (TAC), Malondialdehyde (MDA) and Interleukin-6 (IL-6) were estimated. Serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin and creatinine were estimated. Histopathological examination to liver and kidney was performed. AFs significantly increased FCR and liver weight than control. The levels of SOD and TAC significantly reduced in-group III while MDA and IL-6 increased than control. The levels of AST, ALT and creatinine were significantly (P<0.05) increased in AFs group meanwhile albumin was significantly reduced than control.  Hepatic and renal tissue showed congestion, lymphocytic infiltrations and other retrogressive changes. The co-administration of curcumin with AFs significantly ameliorated the AFs induced adverse effects. Curcumin possesses antioxidant effect that ameliorated aflatoxicosis adverse effects on the kidney and liver.
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