风湿病自身免疫的现代概念

E. Nasonov
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引用次数: 0

摘要

两种基本的病理过程是慢性炎症机制的核心:自身免疫和自身炎症。自身免疫和自身炎症是相互作用的病理过程;它们的发展被认为是在“免疫炎症”连续体的框架内,反映了先天和获得性免疫反应类型之间的密切关系。自身免疫是一大群慢性炎症性人类疾病的主要发病机制,被定义为自身免疫性疾病,其在人群中的发病率超过10%。分子生物学、药物遗传学和生物信息学的进步为个体化医疗概念下自身免疫性风湿病的个体化治疗创造了先决条件。研究免疫发病机制,改进诊断方法,破解分子分类的本质,开发人类自身免疫性疾病的预防和个性化治疗方法是21世纪医学的优先方向之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modern concept of autoimmunity in rheumatology
Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity and autoinflammation are mutually potent pathologic processes; their development is considered within the framework of the “immunoinflammatory” continuum, reflecting the close relationship between innate and acquired types of immune response. Autoimmunity is the leading mechanism of pathogenesis of a large group of chronic inflammatory human diseases, defined as autoimmune diseases, the frequency of which in the population exceeds 10%. Advances in molecular biology, pharmacogenetics and bioinformatics have created prerequisites for individualization of therapy of autoimmune rheumatic diseases within the concept of personalized medicine. The study of immunopathogenesis mechanisms, improvement of diagnostics, deciphering the nature of molecular taxonomy, development of approaches to prevention and personalized therapy of human autoimmune diseases is among the priority directions of medicine of the 21st century.
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