The usefulness of electrophoretic analysis of urinary retinol-binding protein and retinol-binding protein 4 in type 2 diabetes mellitus patients

We measured the urinary excretion of retinol-binding protein (RBP), β 2 -microglobulin ( β 2 -m), albumin, and N-acetyl- β -D-glucosaminidase as well as serum glucose, RBP, β 2 -m, hemoglobin A1c, and creatinine in type 2 diabetes mellitus 158 patients. In urinary RBP, there was a significant difference between the patients who had nephropathy and those without complications. In the cases with nephropathy, urinary RBP had a significantly high value, but no significant difference was observed in the case with retinopathy. There were no significant correlations between urinary RBP and serum RBP. The index of correlation was 0.351. According The main for all three had molecular urinary RBP4, kDa for cases retinopathy, a and an light-colored band seen at 55 kDa, the possibility of early detection of retinopathy by examining these bands.