{"title":"血红蛋白Sogn (β14精氨酸)一种新的血红蛋白变体","authors":"E. Monn, P. Gaffney, H. Lehmann","doi":"10.1111/J.1600-0609.1968.TB01760.X","DOIUrl":null,"url":null,"abstract":"Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability. \n \n \n \nHeterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"61 1","pages":"353-360"},"PeriodicalIF":0.0000,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Haemoglobin Sogn (β14 Arginine) A New Haemoglobin Variant\",\"authors\":\"E. Monn, P. Gaffney, H. Lehmann\",\"doi\":\"10.1111/J.1600-0609.1968.TB01760.X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability. \\n \\n \\n \\nHeterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.\",\"PeriodicalId\":21489,\"journal\":{\"name\":\"Scandinavian journal of haematology\",\"volume\":\"61 1\",\"pages\":\"353-360\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian journal of haematology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/J.1600-0609.1968.TB01760.X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian journal of haematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1600-0609.1968.TB01760.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Haemoglobin Sogn (β14 Arginine) A New Haemoglobin Variant
Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability.
Heterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.
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