{"title":"CRISPR-Cas系统:传染病诊断和治疗的简史和未来","authors":"B. Otlu","doi":"10.5152/IDCM.2019.19007","DOIUrl":null,"url":null,"abstract":"T he discovery of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and CRISPR-Associated System (Cas) have led to revolutionary advancements in almost every field of biology. The CRISPR-Cas system is part of an adaptive immune system in bacteria, and this system protects the organism from invading genetic elements of bacteriophages and plasmids. In this article, the discovery of the CRISPR-Cas system, its mechanism of action, and particularly its use in infectious diseases will be discussed.","PeriodicalId":11964,"journal":{"name":"European Journal of Clinical Microbiology and Infectious Diseases","volume":"67 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"CRISPR-Cas System: A Brief History and Future in the Diagnosis and Treatment of Infectious Diseases\",\"authors\":\"B. Otlu\",\"doi\":\"10.5152/IDCM.2019.19007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"T he discovery of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and CRISPR-Associated System (Cas) have led to revolutionary advancements in almost every field of biology. The CRISPR-Cas system is part of an adaptive immune system in bacteria, and this system protects the organism from invading genetic elements of bacteriophages and plasmids. In this article, the discovery of the CRISPR-Cas system, its mechanism of action, and particularly its use in infectious diseases will be discussed.\",\"PeriodicalId\":11964,\"journal\":{\"name\":\"European Journal of Clinical Microbiology and Infectious Diseases\",\"volume\":\"67 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Clinical Microbiology and Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5152/IDCM.2019.19007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Microbiology and Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/IDCM.2019.19007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CRISPR-Cas System: A Brief History and Future in the Diagnosis and Treatment of Infectious Diseases
T he discovery of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and CRISPR-Associated System (Cas) have led to revolutionary advancements in almost every field of biology. The CRISPR-Cas system is part of an adaptive immune system in bacteria, and this system protects the organism from invading genetic elements of bacteriophages and plasmids. In this article, the discovery of the CRISPR-Cas system, its mechanism of action, and particularly its use in infectious diseases will be discussed.
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