猴子初级运动皮层刺激驱动和意图驱动行为的编码

Keyi Liu, Wenjuan Hu, Yao Chen
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引用次数: 0

摘要

行为可以分为两种模式,一种是在没有刺激的情况下由意图驱动的行为,另一种是对外界刺激的反应。先前的研究表明,这两种运动模式可能是由大脑中不同的生理途径控制的。然而,它们在运动皮层中的神经编码尚不清楚。在这项研究中,我们训练恒河猴进行外部刺激驱动和内部意图驱动的手臂运动任务,并记录初级运动皮层(M1)的神经元活动。我们的目的是比较基于刺激和基于意图的行为模式之间的神经元编码。我们发现,在进行内部意图驱动的手臂运动时,神经元以不同的模式放电。在运动执行阶段,这些神经元在意图型任务和刺激型任务之间没有显著差异。我们还建立了一般线性模型来量化M1神经元在不同动作模式下对运动参数的编码强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Encoding of Stimulus-driven and Intention-driven Actions in Monkey's Primary Motor Cortex
Actions can be divided into two modes, one is driven by intention without stimulus, another is in response to external stimulus. Previous studies have shown that these two modes of movement may be manipulated by different physiological pathways in the brain. However, the neural coding of them in motor cortex is still unknown. In this study, we trained rhesus monkeys performing external stimulus-driven and internal intention-driven arm movement tasks, and recorded neuronal activity in primary motor cortex (M1). We aimed to compare the neuronal coding between stimulus-based and intention-based action modes. We found that neurons fired in different patterns while doing internal intention-driven arm movement. These neurons show no significant difference between intention-based and stimulus-based tasks during movement execution period. We also set up a general linear model to quantify the encoding strength of M1 neurons towards movement parameters in different action modes.
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