改进的RNA-Seq划分线性模型用于异构体定量

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) Pub Date : 2011-11-12 DOI:10.1109/BIBM.2011.102

Brian E. Howard, P. Veronese, S. Heber

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引用次数: 0

摘要

在这里，我们提出了一种扩展我们的形式量化方法，以适应成对末端RNA测序数据。我们探索了几种分区读计数数据的替代方法，以便更好地利用可用的片段大小分布，并减少结果估计的方差。在许多情况下，这大大提高了我们的方法的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Improved RNA-Seq Partitions in Linear Models for Isoform Quantification

Here, we present an extension of our is form quantification method that accommodates paired end RNA Sequencing data. We explore several alternate methods of partitioning read count data in order to better exploit the available fragment size distribution, and to reduce the variance in the resulting estimates. In many cases, this significantly improves the accuracy of our approach.

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来源期刊

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

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