以树脂酸为原料制备脱氢枞酸-铬酚杂化环糊精配合物

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Journal of Moldova Pub Date : 2022-12-01 DOI:10.19261/cjm.2022.942

M. Zveaghintseva, E. Stingaci, S. Pogrebnoi, Lucian Lupascu, A. Barba, G. Duca, V. Valica, Livia Uncu, V. Kravtsov, D. Terteac, A. Brînzan, F. Macaev

{"title":"以树脂酸为原料制备脱氢枞酸-铬酚杂化环糊精配合物","authors":"M. Zveaghintseva, E. Stingaci, S. Pogrebnoi, Lucian Lupascu, A. Barba, G. Duca, V. Valica, Livia Uncu, V. Kravtsov, D. Terteac, A. Brînzan, F. Macaev","doi":"10.19261/cjm.2022.942","DOIUrl":null,"url":null,"abstract":"In this work new methods to obtain complexes from β-cyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation for the resolution of racemic 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol for obtaining micro- and nanoparticles have been optimized. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. The obtained β-complexes of β-cyclodextrin loaded with dehydroabietitoic acid and chromenol hybrid showed good antibacterial activity with MIC and MBC values ranging from 0.72 to 44.45 μM.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"131 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Resin Acids as Raw Material for the Preparation of Cyclodextrin Complexes Loaded with Dehydroabietitoic Acid and Chromenol Hybrid\",\"authors\":\"M. Zveaghintseva, E. Stingaci, S. Pogrebnoi, Lucian Lupascu, A. Barba, G. Duca, V. Valica, Livia Uncu, V. Kravtsov, D. Terteac, A. Brînzan, F. Macaev\",\"doi\":\"10.19261/cjm.2022.942\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this work new methods to obtain complexes from β-cyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation for the resolution of racemic 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol for obtaining micro- and nanoparticles have been optimized. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. The obtained β-complexes of β-cyclodextrin loaded with dehydroabietitoic acid and chromenol hybrid showed good antibacterial activity with MIC and MBC values ranging from 0.72 to 44.45 μM.\",\"PeriodicalId\":9922,\"journal\":{\"name\":\"Chemistry Journal of Moldova\",\"volume\":\"131 1\",\"pages\":\"\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry Journal of Moldova\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19261/cjm.2022.942\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Journal of Moldova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19261/cjm.2022.942","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

本文报道了以β-环糊精和脱氢枞酸为原料制备尺寸在0.1 ~ 250 μm范围内的铬-三唑杂化物的新方法。对外消旋2-叔丁基-3-(1h -1,2,4-三唑-1-基)- 2h -铬-2-醇的捏合、共蒸发和共沉淀法进行了优化。合成的化合物在磷酸盐缓冲液(pH 6.8)中的体外溶出研究表明，与游离形式相比，铬-三唑杂合物在包合物中的溶出速度更快。以脱氢枞酸和铬酚为载体负载β-环糊精的β-配合物具有良好的抗菌活性，其MIC和MBC值在0.72 ~ 44.45 μM之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Resin Acids as Raw Material for the Preparation of Cyclodextrin Complexes Loaded with Dehydroabietitoic Acid and Chromenol Hybrid

In this work new methods to obtain complexes from β-cyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation for the resolution of racemic 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol for obtaining micro- and nanoparticles have been optimized. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. The obtained β-complexes of β-cyclodextrin loaded with dehydroabietitoic acid and chromenol hybrid showed good antibacterial activity with MIC and MBC values ranging from 0.72 to 44.45 μM.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemistry Journal of Moldova CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

12 weeks

期刊介绍： "Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry" seeks to publish experimental or theoretical research results of outstanding significance and timeliness in all fields of Chemistry, including Industrial and Ecological Chemistry. The main goal of this edition is strengthening the Chemical Society of Moldova, following development of research in Moldovan chemical institutions and promotion of their collaboration with international chemical community. Manuscripts are welcome from all countries.