6个月至12岁肺结核患儿血清锌水平

Pediatric Infectious Disease Pub Date : 2015-04-01 DOI:10.1016/j.pid.2015.06.002

Parveen Mittal, Pancham Kalra

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引用次数: 1

摘要

结核病是我国最严重的健康问题之一。结核病和营养不良之间的联系是公认的。结核病可导致营养不良，而营养不良可能易患结核病。结核病的微量营养素状况受到显著影响。在微量营养素中，锌在细胞免疫中起着非常重要的作用。关于锌水平与儿童结核病之间关系的数据有限。目的评价结核病儿童和营养不良儿童的血清锌水平，并比较两者的血清锌水平。方法对帕蒂亚拉市拉金德拉医院儿科收治的100例6个月~ 12岁儿童进行研究，其中50例为结核病患儿，50例为营养不良无结核病患儿。50名年龄和性别匹配的儿童作为对照。结果结核患者血清锌平均水平为45.18±10.05 μg/dl, PEM患者为53.04±7.13 μg/dl，对照组为86.84±15.92 μg/dl。与对照组相比，结核病儿童的血清锌水平明显较低(p <0.0001)。与对照组相比，PEM患儿(但未患结核病)的血清锌水平明显较低(p <0.0001)。此外，与PEM(未患结核病)儿童相比，结核病儿童的血清锌水平明显较低(p <0.05)。结论结核病对血清锌水平有显著影响。

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Serum zinc levels in children 6 months–12 years having tuberculosis

Background

Tuberculosis is one of the most serious health problems in our country.

The association between tuberculosis and malnutrition is well recognized. Tuberculosis can lead to malnutrition, and malnutrition may predispose to tuberculosis. The micronutrient status in tuberculosis is affected significantly. Among the micronutrients, zinc plays a very important role as far as cell-mediated immunity is concerned. Limited data are available on the relationship between zinc levels and tuberculosis in childhood.

Aim

The present study was designed to estimate the serum zinc levels in children with tuberculosis and in children with malnutrition, and to compare the serum zinc levels between them.

Methods

Our study was conducted on 100 children in the age group of 6 months–12 years reporting to Department of Pediatrics, Rajindra Hospital, Patiala, out of which 50 children were those affected by tuberculosis and 50 children were those with malnutrition without tuberculosis. 50 age- and sex-matched children were taken as control.

Results

It was observed that the mean serum zinc levels in TB were 45.18 ± 10.05 μg/dl, in PEM were 53.04 ± 7.13 μg/dl while in controls they were 86.84 ± 15.92 μg/dl. It was seen that serum zinc levels were significantly low in children with TB as compared to controls (p < 0.0001). Serum zinc levels were found to be significantly low in children with PEM (but without TB) as compared to controls (p < 0.0001). Also, serum zinc levels were significantly low in children with TB when compared to children with PEM (without TB) (p < 0.05).

Conclusion

Serum zinc levels are significantly affected in tuberculosis.

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来源期刊

Pediatric Infectious Disease

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