Modeling the Population Growth of the Co-cultured Blood Cells Exposed by Microbubble-mediated Ultrasound

Ultrasound-based drug delivery inspires rigorous experimental studies on the cell experiments involving microbubble-mediated ultrasound. Yet few tools can be found to accelerate the cellular exposure experiments on the heterogeneous-population-based bioeffects under various conditions. In this study, we propose a 2D model which can be used to simulate the population evolution of the co-cultured cells after microbubble-mediated ultrasound is induced. Two update rules based on the experimental data were proposed and incorporated in the simulation procedures. The bioeffects found in the previous experiment, such as cell cycle arrest, are taken into account in the model to simulate the population growth in a co-cultured setting. This model may provide a predictive tool for the multi-cell type responses to ultrasound-induced perforation and facilitate the future experiment design.