Sjögren综合征患者的肺血管疾病(PVD) -一项前瞻性横断面研究

P. Douschan, J. Horwath-winter, J. Hermann, M. Stradner, T. Sassmann, V. Foris, A. Avian, H. Olschewski, G. Kovacs
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引用次数: 0

摘要

背景:干燥综合征可能并发肺动脉高压(PH)。然而,尚无关于其患病率的前瞻性研究数据。目的:我们旨在评估原发性和继发性干燥综合征患者的PVD患病率,包括PH、边缘性mPAP (20-24mmHg)和运动PH (EPH)。方法:连续的干燥综合征患者在休息和运动时进行超声心动图检查。根据他们的静息SPAP和运动时的mPAP/CO斜率,将他们分为低、中、高风险组。高危患者(SPAP≥38mmHg,怀疑PH)建议行右心导管(RHC)。中度危险患者(SPAP 30-37mmHg[疑似边缘性mPAP]或运动espap≥46mmHg + TPR>3WU[疑似EPH])出现症状或峰值vo2明显降低时建议使用RHC。结果:共筛选86例患者(女性81例,年龄58±10岁,原发性干燥症46例)。6例患者静息SPAP≥38mmHg,均符合疑似EPH标准。N=9和N=18分别符合疑似边缘性mPAP和/或EPH的标准。10例患者行RHC。8例诊断为EPH, 1例诊断为边缘性mPAP。结论:在这项评估干燥综合征PVD患病率的首次前瞻性研究中,0/86例患者有明显的PH, N=8例有EPH, N=1例有轻度PAP升高。这些发现与老年和舒张期左室功能障碍有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pulmonary vascular disease (PVD) in patients with Sjögren syndrome - a prospective cross-sectional study
Background: Sjogren syndrome may be complicated by pulmonary hypertension (PH). However, there are no data available from prospective studies regarding its prevalence. Aims: We aimed to assess the prevalence of PVD including PH, borderline mPAP (20-24mmHg) and exercise PH (EPH) in patients with primary and secondary Sjogren syndrome. Methods: Consecutive patients with Sjogren syndrome underwent echocardiography at rest and during exercise. They were assigned to a low-, intermediate- or high-risk group according to their resting SPAP and their mPAP/CO slope during exercise. In high-risk patients (SPAP≥38mmHg, suspected PH) right heart catheterization (RHC) was suggested. Intermediate-risk patients (SPAP 30-37mmHg [suspected borderline mPAP] or exerciseSPAP≥46mmHg + TPR>3WU [suspected EPH]) RHC was advised in case of symptoms or significantly decreased peakVO2. Results: 86 patients were screened (female N=81, age 58±10yrs, primary Sjogren N=46). N=6 patients had a resting SPAP≥38mmHg, all of them meeting criteria for suspected EPH. N=9 and N=18 fulfilled criteria for suspected borderline mPAP and/or EPH, respectively. RHC was performed in 10 patients. EPH was diagnosed in N=8, borderline mPAP in N=1. No patient had PH. Patients with suspected EPH were older (64±10 vs 55±10, p Conclusions: In this first prospective study evaluating the prevalence of PVD in Sjogren syndrome, 0/86 patients had manifest PH, N=8 had EPH and N=1 had mild PAP elevation. These findings were associated with older age and diastolic LV-dysfunction.
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