入院时尿素氮比血清肌酐在预测急性冠脉综合征患者住院预后中的优势

Md Saiful Islam, Mst. Ismot Ara, Md HN Ashiqur Rahman, M. Ullah, Md. Mostafizur Rahman, Md Sarwar Alam, Mamunur Rashid Shikder, Mohammad Abrar Kaiser, Md Aks Zahid Mahmud Khan, Md. Mojibur Rahman
{"title":"入院时尿素氮比血清肌酐在预测急性冠脉综合征患者住院预后中的优势","authors":"Md Saiful Islam, Mst. Ismot Ara, Md HN Ashiqur Rahman, M. Ullah, Md. Mostafizur Rahman, Md Sarwar Alam, Mamunur Rashid Shikder, Mohammad Abrar Kaiser, Md Aks Zahid Mahmud Khan, Md. Mojibur Rahman","doi":"10.3329/cardio.v14i2.58778","DOIUrl":null,"url":null,"abstract":"Background: Serum creatinine and blood urea nitrogen (BUN) are the common markers of renal function and also one of the known predictors of adverse outcomes of acute coronary syndrome (ACS). The aim of this study is to assess the impact of elevated BUN on in-hospital outcome of ACS patients and superiority of BUN over creatinine for the assessment of in-hospital outcome in our setting. Methods: This prospective observational study with purposive sampling of a total of 184 patients was conducted from October, 2009 to September, 2010. Based on normal cut off values (BUN and serum creatinine was <20 mg/dl and <1.4 mg/dl respectively) all the patients were divided into four groups; group I- both BUN and serum creatinine are normal, group-II- normal BUN and high serum creatinine, group-III- high BUN and normal serum creatinine, group-IV- - both BUN and serum creatinine are high. In-hospital data like hemodynamic conditions, heart failure, arrhythmias, conduction abnormalities, death etc. were noted. Assessment of in-hospital outcome of ACS patients and comparison to elevated serum creatinine and elevated BUN was done. Results: ACS patients with only raised BUN level had more occurrence of cardiogenic shock (p=0.008), left ventricular failure (p=0.020), ventricular Tachycardia (p=0.022), ventricular fibrillation (P=0.037) and complete AV block (p=0.022) than those with only raised serum creatinine. In hospital mortality and hospital stay was also increased in ACS patients with elevated BUN than elevated serum creatinine (p value is 0.022 and 0.007 respectively). Conclusion: Incidence of in-hospital death, cardiogenic shock, left ventricular failure, arrhythmia and duration of hospital stay were significantly (p<0.05) higher in patients who had raised BUN than raised serum creatinine. It is observed that elevated BUN is a better predictor of in-hospital outcome of ACS patients than elevated creatinine. Cardiovasc j 2022; 14(2): 135-142","PeriodicalId":9438,"journal":{"name":"Cardiovascular Journal","volume":"40 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Superiority of Admission Blood Urea Nitrogen over Serum Creatinine in Predicting In-Hospital Outcome of Patients with Acute Coronary Syndrome\",\"authors\":\"Md Saiful Islam, Mst. Ismot Ara, Md HN Ashiqur Rahman, M. Ullah, Md. Mostafizur Rahman, Md Sarwar Alam, Mamunur Rashid Shikder, Mohammad Abrar Kaiser, Md Aks Zahid Mahmud Khan, Md. Mojibur Rahman\",\"doi\":\"10.3329/cardio.v14i2.58778\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Serum creatinine and blood urea nitrogen (BUN) are the common markers of renal function and also one of the known predictors of adverse outcomes of acute coronary syndrome (ACS). The aim of this study is to assess the impact of elevated BUN on in-hospital outcome of ACS patients and superiority of BUN over creatinine for the assessment of in-hospital outcome in our setting. Methods: This prospective observational study with purposive sampling of a total of 184 patients was conducted from October, 2009 to September, 2010. Based on normal cut off values (BUN and serum creatinine was <20 mg/dl and <1.4 mg/dl respectively) all the patients were divided into four groups; group I- both BUN and serum creatinine are normal, group-II- normal BUN and high serum creatinine, group-III- high BUN and normal serum creatinine, group-IV- - both BUN and serum creatinine are high. In-hospital data like hemodynamic conditions, heart failure, arrhythmias, conduction abnormalities, death etc. were noted. Assessment of in-hospital outcome of ACS patients and comparison to elevated serum creatinine and elevated BUN was done. Results: ACS patients with only raised BUN level had more occurrence of cardiogenic shock (p=0.008), left ventricular failure (p=0.020), ventricular Tachycardia (p=0.022), ventricular fibrillation (P=0.037) and complete AV block (p=0.022) than those with only raised serum creatinine. In hospital mortality and hospital stay was also increased in ACS patients with elevated BUN than elevated serum creatinine (p value is 0.022 and 0.007 respectively). Conclusion: Incidence of in-hospital death, cardiogenic shock, left ventricular failure, arrhythmia and duration of hospital stay were significantly (p<0.05) higher in patients who had raised BUN than raised serum creatinine. It is observed that elevated BUN is a better predictor of in-hospital outcome of ACS patients than elevated creatinine. Cardiovasc j 2022; 14(2): 135-142\",\"PeriodicalId\":9438,\"journal\":{\"name\":\"Cardiovascular Journal\",\"volume\":\"40 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/cardio.v14i2.58778\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/cardio.v14i2.58778","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:血清肌酐和血尿素氮(BUN)是肾功能的常见指标,也是已知的急性冠脉综合征(ACS)不良结局的预测指标之一。本研究的目的是评估BUN升高对ACS患者住院结果的影响,以及在我们的环境中BUN优于肌酐评估住院结果。方法:本研究于2009年10月至2010年9月对184例患者进行前瞻性观察性研究。根据正常临界值(BUN <20 mg/dl,血清肌酐<1.4 mg/dl)将患者分为4组;组- BUN和血清肌酐均正常,组- BUN正常且血清肌酐偏高,组- BUN高且血清肌酐正常,组- BUN高且血清肌酐正常,组- BUN和血清肌酐均高。记录了血流动力学状况、心力衰竭、心律失常、传导异常、死亡等住院数据。评估ACS患者的住院结果,并比较血清肌酐升高和BUN升高。结果:单纯BUN升高的ACS患者发生心源性休克(p=0.008)、左心衰(p=0.020)、室性心动过速(p=0.022)、心室颤动(p= 0.037)和完全性房室传导阻滞(p=0.022)的比例高于单纯血清肌酐升高的ACS患者。与血清肌酐升高相比,BUN升高的ACS患者住院死亡率和住院时间明显增加(p值分别为0.022和0.007)。结论:BUN升高患者的院内死亡、心源性休克、左心衰、心律失常发生率及住院时间均显著高于血清肌酐升高患者(p<0.05)。观察到BUN升高比肌酐升高更能预测ACS患者的住院预后。心血管病杂志[j] 2022;14 (2): 135 - 142
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Superiority of Admission Blood Urea Nitrogen over Serum Creatinine in Predicting In-Hospital Outcome of Patients with Acute Coronary Syndrome
Background: Serum creatinine and blood urea nitrogen (BUN) are the common markers of renal function and also one of the known predictors of adverse outcomes of acute coronary syndrome (ACS). The aim of this study is to assess the impact of elevated BUN on in-hospital outcome of ACS patients and superiority of BUN over creatinine for the assessment of in-hospital outcome in our setting. Methods: This prospective observational study with purposive sampling of a total of 184 patients was conducted from October, 2009 to September, 2010. Based on normal cut off values (BUN and serum creatinine was <20 mg/dl and <1.4 mg/dl respectively) all the patients were divided into four groups; group I- both BUN and serum creatinine are normal, group-II- normal BUN and high serum creatinine, group-III- high BUN and normal serum creatinine, group-IV- - both BUN and serum creatinine are high. In-hospital data like hemodynamic conditions, heart failure, arrhythmias, conduction abnormalities, death etc. were noted. Assessment of in-hospital outcome of ACS patients and comparison to elevated serum creatinine and elevated BUN was done. Results: ACS patients with only raised BUN level had more occurrence of cardiogenic shock (p=0.008), left ventricular failure (p=0.020), ventricular Tachycardia (p=0.022), ventricular fibrillation (P=0.037) and complete AV block (p=0.022) than those with only raised serum creatinine. In hospital mortality and hospital stay was also increased in ACS patients with elevated BUN than elevated serum creatinine (p value is 0.022 and 0.007 respectively). Conclusion: Incidence of in-hospital death, cardiogenic shock, left ventricular failure, arrhythmia and duration of hospital stay were significantly (p<0.05) higher in patients who had raised BUN than raised serum creatinine. It is observed that elevated BUN is a better predictor of in-hospital outcome of ACS patients than elevated creatinine. Cardiovasc j 2022; 14(2): 135-142
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信