Samantha M. Solon-Biet , Devin Wahl , David Raubenheimer , Victoria C. Cogger , David G. Le Couteur , Stephen J. Simpson
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The geometric framework: An approach for studying the impact of nutrition on healthy aging
The most robust interventions that impact on the biological processes of aging and age-related diseases are nutritional (caloric restriction, protein restriction, intermittent fasting) or those pharmacological and genetic interventions that act on nutrient sensing pathways. The best established nutritional intervention is caloric restriction, but this is not feasible in most humans; therefore, other nutritional interventions that influence aging but do not involve protracted periods of fasting have been studied. The Geometric Framework provides a powerful research tool for disentangling the effects of various nutrients and calorie intake, in both restricted and ad libitum-fed diets, on phenotypic outcomes such as aging and lifespan. This approach can also be applied to understanding the complex network of nutrient sensing pathways, potentially identifying new targets for the development of drugs that influence healthy aging.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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