Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in Ménière’s disease and vestibular neuritis

Abstract Objective several hypothesis including viral infection, vascular disturbance, and immune-mediated mechanisms have been proposed in Menière disease (MD) and vestibular neuritis (VN) and the role of inflammation has been also investigated. To evaluate the role of neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and metabolic parameters in MD and VN patients. Methods we retrospectively studied 120 subjects (40 affected by MD, 40 by VN and 40 normal controls). We analyzed glycaemia, Haematocrit Blood Test (HCT), leukocytes, neutrophils, lymphocytes, platelets, cholesterol, prothrombin time and the related international normalized ratio (PT-INR), fibrinogen, erythrocyte sedimentation rate (ESR), NLR and PLR. Results Neutrophils, leukocytes, cholesterol, ESR, NLR and PLR values of MD patients are significantly higher than normal controls. Higher significant values are reported for glycaemia, neutrophils, lymphocytes, leucocyte, fibrinogen, ESR, NLR and PLR in VN patients compared to NC. Conclusions High levels of NLR and PLR indicate the presence of an acute inflammatory state in both MD and VN. Our data confirm the role of proinflammatory state leading to microvascular injury together with risk factors for atherogenesis.