强太赫兹脉冲诱导人体皮肤组织模型中钙信号的强度依赖性抑制

2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) Pub Date : 2018-09-01 DOI:10.1109/IRMMW-THZ.2018.8509862

Cameron M. Hough, D. Purschke, Chenxi Huang, L. Titova, O. Kovalchuk, Brad J. Warkentin, Frank A. Hcgmann

{"title":"强太赫兹脉冲诱导人体皮肤组织模型中钙信号的强度依赖性抑制","authors":"Cameron M. Hough, D. Purschke, Chenxi Huang, L. Titova, O. Kovalchuk, Brad J. Warkentin, Frank A. Hcgmann","doi":"10.1109/IRMMW-THZ.2018.8509862","DOIUrl":null,"url":null,"abstract":"The biological effects of intense THz pulses on human skin tissue models are investigated by applying gene ontology and pathway perturbation analyses to measured global differential gene expression profiles. Biological processes and cellular structures that regulate epidermal differentiation are highly overrepresented by THz-affected genes, and several signaling pathways that regulate the development of human cancer are predicted to be dysregulated. In particular, the calcium signaling pathway is predicted to be suppressed by THz exposures, and this effect increases with THz intensity. Mechanisms for the predicted suppression are identified and discussed in the context of potential clinical considerations of intense THz pulses.","PeriodicalId":6653,"journal":{"name":"2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"21 1","pages":"1-3"},"PeriodicalIF":0.0000,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Intensity-dependent Suppression of Calcium Signaling in Human Skin Tissue Models Induced by Intense THz Pulses\",\"authors\":\"Cameron M. Hough, D. Purschke, Chenxi Huang, L. Titova, O. Kovalchuk, Brad J. Warkentin, Frank A. Hcgmann\",\"doi\":\"10.1109/IRMMW-THZ.2018.8509862\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The biological effects of intense THz pulses on human skin tissue models are investigated by applying gene ontology and pathway perturbation analyses to measured global differential gene expression profiles. Biological processes and cellular structures that regulate epidermal differentiation are highly overrepresented by THz-affected genes, and several signaling pathways that regulate the development of human cancer are predicted to be dysregulated. In particular, the calcium signaling pathway is predicted to be suppressed by THz exposures, and this effect increases with THz intensity. Mechanisms for the predicted suppression are identified and discussed in the context of potential clinical considerations of intense THz pulses.\",\"PeriodicalId\":6653,\"journal\":{\"name\":\"2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)\",\"volume\":\"21 1\",\"pages\":\"1-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/IRMMW-THZ.2018.8509862\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IRMMW-THZ.2018.8509862","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

摘要

通过应用基因本体和途径摄动分析测量的全球差异基因表达谱，研究了强太赫兹脉冲对人体皮肤组织模型的生物学效应。太赫兹影响基因高度代表了调节表皮分化的生物过程和细胞结构，并且一些调节人类癌症发展的信号通路被预测失调。特别是，钙信号通路预计会受到太赫兹暴露的抑制，并且这种影响会随着太赫兹强度的增加而增加。在强太赫兹脉冲潜在临床考虑的背景下，确定并讨论了预测抑制的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Intensity-dependent Suppression of Calcium Signaling in Human Skin Tissue Models Induced by Intense THz Pulses

The biological effects of intense THz pulses on human skin tissue models are investigated by applying gene ontology and pathway perturbation analyses to measured global differential gene expression profiles. Biological processes and cellular structures that regulate epidermal differentiation are highly overrepresented by THz-affected genes, and several signaling pathways that regulate the development of human cancer are predicted to be dysregulated. In particular, the calcium signaling pathway is predicted to be suppressed by THz exposures, and this effect increases with THz intensity. Mechanisms for the predicted suppression are identified and discussed in the context of potential clinical considerations of intense THz pulses.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

自引率

0.00%

发文量