探索人类疾病小鼠模型的工具

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2016-06-01 DOI:10.1016/j.ddmod.2017.07.004

Melissa Haendel , Irene Papatheodorou , Anika Oellrich , Christopher J. Mungall , Nicole Washington , Suzanna E. Lewis , Peter N. Robinson , Damian Smedley

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引用次数: 0

摘要

尽管存在重大的计算挑战，但最近已经开发了许多工具来利用小鼠来模拟人类疾病。在这里，我们回顾了这些工具，并展示了它们如何应用于候选基因和治疗靶点的鉴定，以及用于机制研究和药物验证的小鼠模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tools for exploring mouse models of human disease

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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发文量

期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.