唾液粘度的变异性-潜在的影响

Lara Eltze, Maren Eltze, Antonio G. García
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引用次数: 0

摘要

随着新型COVID-19检测技术的发展,唾液作为快速检测的替代生物样本越来越受到关注。唾液检测的吸引力在于样本采集的便利性,以及整个采集过程中患者的舒适度。因此,由于唾液黏度对其内部物质和分子的运动和相互作用的影响,描述唾液黏度的特征变得越来越重要。影响唾液粘度的特征包括聚集物的存在、温度的变化以及样品收集和测试之间的时间间隔。了解物理化学性质和温度如何影响唾液的粘度,对于制定正确的唾液测试样品处理指南,以确保一致和可靠的结果是很重要的。在本研究中,对唾液的被动采样进行了分析。这种类型的收集确保了更均匀的唾液成分,这表明粘度的变化可以完全归因于收集后唾液处理的变化。数据表明,唾液黏度在收集唾液样本后立即达到最大,随着唾液中聚集物数量的增加而增加,当样本被冷冻和解冻到室温时,黏度急剧下降。这些发现表明,为了确保定量唾液检测结果的准确性和一致性,方案应该有利于在采集样本后立即进行检测。这些结果对优化唾液测试的影响是深远的。基于唾液的检测的价值远远超出了COVID-19或其他疾病的检测。它在了解日常水合状态波动和其他健康应用方面也越来越实用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variability of Saliva Viscosity - Potential Impact
As novel COVID-19 testing develops, saliva has become of increasing interest as an alternate biological sample for rapid testing. The appeal in saliva-based testing lies within the ease of which samples are collected, as well as patient comfort throughout the collection process. With this, it has become increasingly important to delineate the characteristics of saliva viscosity due to its effects on the movement and interactions of the substances and molecules found within it. The characteristics that affect saliva viscosity include the presence of aggregates, variations in temperature, and time elapsed between sample collection and testing. Understanding how physicochemical properties and temperature affect saliva’s viscosity are important in generating guidelines for proper sample handling in saliva testing to ensure consistent and reliable results. In this study, passive sampling of saliva was analyzed. This type of collection ensures a more uniform saliva composition, suggesting that variations in viscosity can be attributed solely to modifications in saliva handling post-collection. The data suggested that saliva viscosity is greatest immediately following collection of the saliva sample, increases with higher quantities of aggregates in saliva, and decreases tremendously when the sample has been frozen and thawed to room temperature. These findings suggest that to ensure accuracy and uniformity in quantitative saliva-based test results, protocols should favor the testing of a sample immediately following its collection. The implications of these results in optimizing saliva testing are far reaching. The value of saliva based testing extends far beyond COVID-19 or other disease testing. It is also gaining utility in understanding daily fluctuations in hydration state and in other wellness applications.
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