存在接触介导的宿主休眠的微生物病毒流行

IF 0.6 4区 数学 Q4 STATISTICS & PROBABILITY
J. Blath, Andr'as T'obi'as
{"title":"存在接触介导的宿主休眠的微生物病毒流行","authors":"J. Blath, Andr'as T'obi'as","doi":"10.1051/ps/2022022","DOIUrl":null,"url":null,"abstract":"We investigate a stochastic individual-based model for the population dynamics of host-virus systems where the microbial hosts may transition into a dormant state upon contact with virions, thus evading infection. Such a contact-mediated defence mechanism was described in Bautista&al. (2015) for an archaeal host, while Jackson-Fineran (2019) and Meeske&al. (2019) describe a related, CRISPR-Cas induced, dormancy defense of bacterial hosts to curb phage epidemics. We first analyse the effect of the dormancy-related model parameters on the probability and time of invasion of a newly arriving virus into a resident host population. Given successful invasion, we then show that the emergence (with high probability) of a persistent virus infection (‘epidemic’) in a large host population can be determined by the existence of a coexistence equilibrium for the underlying dynamical system. That is an extension of a dynamical system considered by Beretta-Kuang (1998), known to exhibit a Hopf bifurcation, giving rise to a ‘paradox of enrichment’. We verify that the additional dormancy component can, for certain parameter ranges, prevent the associated loss of stability. Moreover, the presence of contact-mediated dormancy enables the host population to attain higher equilibrium sizes - and still avoid a persistent epidemic - than hosts without this trait.","PeriodicalId":51249,"journal":{"name":"Esaim-Probability and Statistics","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Microbial virus epidemics in the presence of contact-mediated host dormancy\",\"authors\":\"J. Blath, Andr'as T'obi'as\",\"doi\":\"10.1051/ps/2022022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We investigate a stochastic individual-based model for the population dynamics of host-virus systems where the microbial hosts may transition into a dormant state upon contact with virions, thus evading infection. Such a contact-mediated defence mechanism was described in Bautista&al. (2015) for an archaeal host, while Jackson-Fineran (2019) and Meeske&al. (2019) describe a related, CRISPR-Cas induced, dormancy defense of bacterial hosts to curb phage epidemics. We first analyse the effect of the dormancy-related model parameters on the probability and time of invasion of a newly arriving virus into a resident host population. Given successful invasion, we then show that the emergence (with high probability) of a persistent virus infection (‘epidemic’) in a large host population can be determined by the existence of a coexistence equilibrium for the underlying dynamical system. That is an extension of a dynamical system considered by Beretta-Kuang (1998), known to exhibit a Hopf bifurcation, giving rise to a ‘paradox of enrichment’. We verify that the additional dormancy component can, for certain parameter ranges, prevent the associated loss of stability. Moreover, the presence of contact-mediated dormancy enables the host population to attain higher equilibrium sizes - and still avoid a persistent epidemic - than hosts without this trait.\",\"PeriodicalId\":51249,\"journal\":{\"name\":\"Esaim-Probability and Statistics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2021-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Esaim-Probability and Statistics\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://doi.org/10.1051/ps/2022022\",\"RegionNum\":4,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"STATISTICS & PROBABILITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Esaim-Probability and Statistics","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1051/ps/2022022","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"STATISTICS & PROBABILITY","Score":null,"Total":0}
引用次数: 3

摘要

我们研究了一个随机的基于个体的宿主-病毒系统种群动力学模型,其中微生物宿主在接触病毒粒子后可能进入休眠状态,从而逃避感染。Bautista&al描述了这种接触介导的防御机制。(2015),而Jackson-Fineran(2019)和Meeske&al。(2019)描述了一种相关的,CRISPR-Cas诱导的细菌宿主休眠防御,以抑制噬菌体流行。我们首先分析了与休眠相关的模型参数对新到达的病毒入侵常驻宿主种群的概率和时间的影响。在成功入侵的情况下,我们随后表明,在大量宿主种群中出现(高概率)持续病毒感染(“流行病”)可以由潜在动力系统的共存平衡的存在决定。这是Beretta-Kuang(1998)认为的动力系统的延伸,已知表现出Hopf分岔,产生“富集悖论”。我们验证了额外的休眠组件可以,在某些参数范围内,防止相关的稳定性损失。此外,与没有这种特性的宿主相比,接触介导的休眠使宿主种群能够达到更高的平衡规模,并且仍然避免持续流行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbial virus epidemics in the presence of contact-mediated host dormancy
We investigate a stochastic individual-based model for the population dynamics of host-virus systems where the microbial hosts may transition into a dormant state upon contact with virions, thus evading infection. Such a contact-mediated defence mechanism was described in Bautista&al. (2015) for an archaeal host, while Jackson-Fineran (2019) and Meeske&al. (2019) describe a related, CRISPR-Cas induced, dormancy defense of bacterial hosts to curb phage epidemics. We first analyse the effect of the dormancy-related model parameters on the probability and time of invasion of a newly arriving virus into a resident host population. Given successful invasion, we then show that the emergence (with high probability) of a persistent virus infection (‘epidemic’) in a large host population can be determined by the existence of a coexistence equilibrium for the underlying dynamical system. That is an extension of a dynamical system considered by Beretta-Kuang (1998), known to exhibit a Hopf bifurcation, giving rise to a ‘paradox of enrichment’. We verify that the additional dormancy component can, for certain parameter ranges, prevent the associated loss of stability. Moreover, the presence of contact-mediated dormancy enables the host population to attain higher equilibrium sizes - and still avoid a persistent epidemic - than hosts without this trait.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Esaim-Probability and Statistics
Esaim-Probability and Statistics STATISTICS & PROBABILITY-
CiteScore
1.00
自引率
0.00%
发文量
14
审稿时长
>12 weeks
期刊介绍: The journal publishes original research and survey papers in the area of Probability and Statistics. It covers theoretical and practical aspects, in any field of these domains. Of particular interest are methodological developments with application in other scientific areas, for example Biology and Genetics, Information Theory, Finance, Bioinformatics, Random structures and Random graphs, Econometrics, Physics. Long papers are very welcome. Indeed, we intend to develop the journal in the direction of applications and to open it to various fields where random mathematical modelling is important. In particular we will call (survey) papers in these areas, in order to make the random community aware of important problems of both theoretical and practical interest. We all know that many recent fascinating developments in Probability and Statistics are coming from "the outside" and we think that ESAIM: P&S should be a good entry point for such exchanges. Of course this does not mean that the journal will be only devoted to practical aspects.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信