INTEGRAL ASSESSMENT OF NON-SPECIFIC LIPID PEROXIDATION REACTIONS IN ADOLESCENT GIRLS OF THE SIBERIAN ETHNOUS

Introduction: Integral parameters, in particular, the oxidative stress coefficient, created by Scientific Centre for Family Health and Human Reproduction Problems, are more informative in contrast to individual indicators and can be used both for evaluation of pathological conditions and compensatory-adaptive reactions of the organism. The general decrease of the adaptation possibilities in the female population, especially indigenous peoples as a part of the reproductive potential of the nation has been noted. The estimation of the integral coefficient in adolescent girls living in different territories and belonging to different ethnic groups is topical. Aim: to investigate an integral coefficient the activity of nonspecific reactions of lipid peroxidation in adolescent girls of the Buryat, Evenki and Tofalar ethnic groups, as compared to the indigenous ethnic groups, by applying. Methods: The 190 adolescent girls (Buryats, Evenki and Tofalar, and non-indigenous population (for example of Russians)) living in the Irkutsk region were the objects of research. The survey was carried out in expeditionary conditions, in the territories of compact residence of ethnic groups. To calculate the integral coefficient (oxidative stress coefficient - OSC) spectrophotometry and fluorometry methods we used. The individual indicators: primary, secondary and final products of lipid peroxidation and antioxidant defense components were measured. Results: According to the obtained data, a lower content of diene conjugates (DC) (2.41 times lower; p0.0001), ketodienes and conjugated trienes (KD and СT) (2.10 times lower; p=0.0003), -tocopherol (1.38 times lower p0.0001) with elevated levels of TBA-active products (1.53 times higher (p=0.0074) and superoxide dismutase activity (p=0.0008) in the Buryat ethnic girls group relative to similar parameters of girls in the non-ingenious population was observed. Girls of the Evenki ethnic group had higher values of -tocopherol (1.29 times higher; p=0.0136) and reduced form of glutathione (1.28 times higher; p=0.0012) compared to those of the non-indigenous population. Girls of Tofalar ethnic group had higher values of DC (1,5 times higher; p=0,0009), -tocopherol (1,28 times higher; p=0,0227) and retinol (1,34 times higher; p=0,0420), with reduced values of KD and CT (1,43 times lower; p=0,0044) compared to those of the corresponding non-indigenous population. Integral analysis of the non-specific reactions of lipid peroxidation state by integral coefficient showed its maximum values in the representatives of the Evenki ethnos and reduced values in the girls of Tofalar ethnos. Conclusion: The integral evaluation of the activity of nonspecific lipid peroxidation reactions in adolescent girls belonging to different Siberian ethnic groups has revealed certain differences, which are evolutionarily deterministic and may serve as a basis for further monitoring of health conditions and developing regional ethnospecific measures for the diseases prevention.