睾丸肿瘤的保守手术

Soraia Rodrigues , Vanessa Metrogos , Marco Dores , José João Marques , Miguel Rodrigues , Miguel Cabrita , Gilberto Rosa , Aníbal Coutinho
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引用次数: 0

摘要

恶性生殖细胞肿瘤占睾丸肿块的大多数;根据目前的知识,根治性睾丸切除术仍然是治疗这类癌症的标准治疗方法。然而,在某些情况下,保留睾丸的手术(TSS)可以作为根治性手术的替代方案,特别是在患有小睾丸肿块(STM)的患者中。目的综述目前保留睾丸手术的适应症、功能及肿瘤结果。材料与方法在Medline数据库(PubMed)中检索相关文献,检索关键词为:“睾丸保留手术”、“睾丸部分切除术”、“睾丸肿瘤”、“睾丸小肿块/肿瘤”。检索范围为2010年至今发表的英文文章。结果没有发现有高水平证据的随机对照试验/研究比较TSS和根治性睾丸切除术。TSS的适应症仍有争议,特别是对侧睾丸正常的患者。保留器官手术似乎是一个可行的治疗选择,患者的小的不可触及的睾丸肿块(与<长轴20mm),双侧肿瘤或单个睾丸。冷冻切片检查在该技术中起着决定性的作用,因为它可以区分恶性和良性肿瘤,并评估手术边缘的状态。回顾性分析的中期和长期随访结果显示,没有明显的局部和/或远处复发风险。结论对于有选择的病例,保留睾丸器官手术是安全可行的。为了使TSS成为根治性手术的真正替代方案,以及评估肿瘤安全性和保留睾丸的真正功能益处,需要前瞻性的多中心和高水平的证据研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cirurgia conservadora nos tumores do testículo

Introduction

Malignant germ cell tumors represent the majority of testicular masses; according to current knowledge, radical orchiectomy remains the standard of care in the management of this type of cancer. However, testis‐sparing surgery (TSS) can be an alternative to radical surgery in selected cases, particularly in patients with small testicular masses (STM).

Objective

The authors conducted a review of the current indications for performing testicular sparing surgery as well as functional and oncological results of it.

Material and methods

We conducted a literature search in Medline database (PubMed) using the keywords: “testis sparing surgery”, “partial orchiectomy”, ‘testis tumor’, ‘small testicular mass/tumor’. The search was limited to article in English language, published from 2010 to the current date.

Results

randomized controlled trials/studies with high level of evidence that compare TSS with radical orchiectomy were not found. Indications for TSS are still controversial, particularly in patients with normal contralateral testis. The organ sparing surgery seems a viable therapeutic option for patients with small non‐palpable testicular mass (with < 20 mm major axis), bilateral tumors or single testicle. The frozen section examination plays a decisive role in the technique, since it allows the distinction between malignant and benign neoplasms, as well as assessing the status of surgical margins. The medium and long follow‐up results of the analyzed retrospective studies revealed no significant risk of local and/or distant relapses.

Conclusion

Regarding the testis, the organ‐sparing surgery can be adopted safely in the treatment of selected cases. Prospective multicentric and high level of evidence studies are needed in order for TSS become a real alternative to radical surgery, as well to evaluate the oncological safety and real functional benefits of preserving the testis.

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