亚临床主动脉粥样硬化的年龄和性别分布:Framingham心脏研究的磁共振成像检查

F. Jaffer, C. O’Donnell, M. Larson, S. K. Chan, K. Kissinger, Michelle J. Kupka, Carol J. Salton, René M. Botnar, D. Levy, W. Manning
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引用次数: 213

摘要

尸检数据显示亚临床主动脉粥样硬化与心血管疾病之间存在相关性。因此,亚临床动脉粥样硬化的无创心血管磁共振(CMR)可能提供一种新的心血管风险测量方法,但尚未应用于基于无症状人群的队列,以建立年龄和性别特异性的规范数据。在弗雷明汉心脏研究的后代队列中,无临床明显冠状动脉疾病的参与者从性别、年龄四分位数和弗雷明汉冠状动脉风险评分的五分位数中随机抽样。受试者(318例,年龄60±9岁,年龄36 ~ 78岁,51%为女性)行ecg门控t2加权黑血胸腹主动脉CMR扫描。CMR显示38%的女性和41%的男性存在主动脉粥样硬化。斑块患病率和所有斑块负荷指标均随年龄增长而增加,且无论男女,在所有年龄组中,腹部均大于胸部。此外,经年龄调整后,Framingham冠状动脉风险评分与女性的所有斑块患病率和负担指标显著相关,但仅与男性相关。这些无创CMR数据扩展了先前基于尸检的亚临床动脉粥样硬化患病率估计,并可能有助于为未来的风险分层研究和受影响个体的治疗奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age and Sex Distribution of Subclinical Aortic Atherosclerosis: A Magnetic Resonance Imaging Examination of the Framingham Heart Study
Autopsy data demonstrate a correlation between subclinical aortic atherosclerosis and cardiovascular disease. Therefore, noninvasive cardiovascular magnetic resonance (CMR) of subclinical atherosclerosis may provide a novel measure of cardiovascular risk, but it has not been applied to an asymptomatic population-based cohort to establish age- and sex-specific normative data. Participants in the Framingham Heart Study offspring cohort who were free of clinically apparent coronary disease were randomly sampled from strata of sex, quartiles of age, and quintiles of Framingham Coronary Risk Score. Subjects (n=318, aged 60±9 years, range 36 to 78 years, 51% women) underwent ECG-gated T2-weighted black-blood thoracoabdominal aortic CMR scanning. CMR evidence of aortic atherosclerosis was noted in 38% of the women and 41% of the men. Plaque prevalence and all measures of plaque burden increased with age group and were greater in the abdomen than in the thorax for both sexes and across all age groups. In addition, the Framingham Coronary Risk Score was significantly correlated with all plaque prevalence and burden measures for women but only for men after age adjustment. These noninvasive CMR data extend the prior autopsy-based prevalence estimates of subclinical atherosclerosis and may help to lay the foundation for future studies of risk stratification and treatment of affected individuals.
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