在复杂治疗方案的影响下,不同程度合并肥胖的非酒精性脂肪性肝炎期非酒精性脂肪性肝病孕妇细胞因子谱的状态

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
L. V. Bahnii, S. Heriak, N. I. Bahnii
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引用次数: 0

摘要

本研究的目的:评价不同程度肥胖的非酒精性脂肪性肝炎(NASH)阶段非酒精性脂肪性肝病(NAFLD)孕妇在复杂治疗方案的影响下,细胞因子谱状态。材料和方法。我们研究了197例伴有NASH合并肥胖的NAFLD孕妇。主要ⅰ组为98例不同程度肥胖的NASH期NAFLD孕妇,根据体重指数(BMI)分为3个亚组。其中,BMI为25.0 ~ 29.9 kg/m2的孕妇26例纳入IA组,BMI为30.0 ~ 34.9 kg/m2的孕妇48例纳入IB组,BMI为35.0 ~ 39.9 kg/m2的孕妇24例纳入IC组。主要组的所有孕妇都接受了复合治疗,包括维生素E的剂量为400 IU/天,熊去氧胆酸(UDCA)的剂量为15 mg/kg/天,左旋肉碱的剂量为3g /天。对照组为69例NASH合并腹部肥胖期NAFLD患者,分别对应主组的亚组(IIA - 23例,IIB - 25例,IIC - 21例孕妇),均接受基础治疗。对照组由30名健康女性组成。elisa法检测各组细胞因子IL-1β、IL-6、IL-10、TNF-α水平。对患有NASH和肥胖的妇女的细胞因子谱的分析显示,在检查组中存在全身性炎症联系,这表现为孕妇血清中促炎水平升高和抗炎白细胞介素水平降低。综合治疗的处方有助于降低炎症反应的活性,这表现为细胞因子谱指标水平的改善。妊娠期NASH伴随着细胞因子谱的显著变化。维生素E、UDCA和左旋肉碱复合治疗处方对NASH期NAFLD孕妇有效,其累积和增强作用通过使细胞因子水平正常化来减少全身性炎症的表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The state of the cytokine profile in pregnant women with non-alcoholic fatty liver disease at the stage of non-alcoholic steatohepatitis with varying degrees of comorbid obesity under the influence of the developed complex therapy program
The aim of the study: to evaluate the cytokine profile state in pregnant women with non-alcoholic fatty liver disease (NAFLD) at the stage of non-alcoholic steatohepatitis (NASH) with varying degrees of obesity under the influence of the developed complex therapy program. Material and methods. We examined 197 pregnant women with NAFLD at the stage of NASH in combination with obesity. The main group I consisted of 98 pregnant women with NAFLD at the stage of NASH with varying degrees of obesity, who were divided into 3 subgroups depending on body mass index (BMI). Among them, 26 pregnant women with BMI of 25.0–29.9 kg/m2 were included in IA group, 48 pregnant women with BMI of 30.0–34.9 kg/m2 were included in IB group, and 24 pregnant women with BMI of 35.0–39.9 kg/m2 – in IC group. All pregnant women in the main group were prescribed complex therapy including vitamin E at a dose of 400 IU/day, ursodeoxycholic acid (UDCA) at a dose of 15 mg/kg/day, and L-carnitine at a dose of 3 g per day. The comparison group consisted of 69 women with NAFLD at the stage of NASH and abdominal obesity, who corresponded to subgroups of the main group (IIA – 23 patients, IIB – 25 women, IIC – 21 pregnant women) and received basic therapy. The control group consisted of 30 healthy women. To evaluate the cytokine profile, levels of IL-1β, IL-6, IL-10 and TNF-α were determined by ELISPOT. Results. Analysis of the cytokine profile in women with NASH and obesity showed the presence of systemic inflammation links in the examined groups, which was manifested by increased levels of pro-inflammatory and decreased levels of anti-inflammatory interleukins in blood serum of pregnant women. A prescription of the complex treatment contributed to a decreased activity of the inflammatory response, which was manifested by an improvement in the levels of cytokine profile indicators. Conclusions. NASH during pregnancy is accompanied by significant changes in the cytokine profile. The prescription of complex therapy in the form of vitamin E, UDCA and L-carnitine is effective in the treatment of pregnant women with NAFLD at the stage of NASH due to cumulative and potentiating effects, reducing manifestations of systemic inflammation by normalizing the level of cytokines.
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
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8 weeks
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