儿童嗜酸性粒细胞性食管炎与胃食管反流病的超声诊断价值

IF 0.4 4区 医学 Q4 PEDIATRICS
M. Khademian, H. Saneian, Maryam Riahinezhad, Victoria Chegini, F. Tavakoli, F. Famouri, Peiman Nasri, Mehri Khoshhali, R. Kelishadi
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引用次数: 0

摘要

背景:嗜酸性食管炎(EoE)是一种由免疫系统反应引起的累及食管的疾病,其临床症状与胃食管反流病(GERD)相似。目前,诊断本病的唯一确定方法是内镜检查和食管组织活检。目的:在本研究中,我们探讨超声在区分EoE与GERD和正常模式的诊断价值。此外,我们评估了用侵入性内窥镜方法代替超声诊断和随访EoE的可能性。方法:对4-12岁儿童进行横断面研究,分为三组明确诊断为GERD、EoE和健康对照组。每组30名参与者接受超声参数评估。各组间比较所得值。通过受者工作特征曲线分析确定超声表现的敏感性和特异性。结果:三组间超声表现:颈、腹食道壁厚、膨胀性、胃壁厚度、颈段食道直径均有显著差异。EoE组腹部食管壁厚度平均±SD最高,为2.73±0.66 mm,胃壁厚度为4.30±0.79 mm,颈段食管壁厚度为2.32±1.21 mm。胃食管反流组颈段食管直径平均值±SD最小,腹部食管膨胀性最小。另一方面,这一组有最高的平均膨胀率的颈部食管。胃壁厚度和腹部食管壁厚度区分EoE与对照组的最高曲线下面积(AUC)分别为0.83和0.80。胃壁厚度和颈食管壁厚度区分EoE和GERD的最高auc分别为0.80和0.71。结论:虽然EoE组超声表现的平均值与对照组和GERD组有显著差异,但区分EoE与对照组和GERD组的能力中等(0.70
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic Value of Ultrasound Findings in Eosinophilic Esophagitis Versus Gastroesophageal Reflux Disease in Children
Background: Eosinophilic esophagitis (EoE) is a disease involving the esophagus due to an immune system reaction and has clinical symptoms similar to gastroesophageal reflux disease (GERD). Currently, the only definitive way to diagnose this disease is the endoscopy and biopsy of the esophageal tissue. Objectives: In this study, we investigated the diagnostic value of ultrasound to differentiate EoE from GERD and normal patterns. In addition, we assessed the possibility of replacing ultrasound with an invasive endoscopic method for the diagnosis and follow-up of EoE. Methods: This cross-sectional study was conducted on 4-12-year-old children in three groups of definitely diagnosed GERD, EoE, and healthy controls. Each group consisted of 30 participants who were evaluated for ultrasound parameters. The obtained values were compared between groups. The sensitivity and specificity of ultrasound findings were determined by receiver operating characteristic curve analysis. Results: Ultrasound findings, including wall thickness and distensibility of the cervical and abdominal esophagus, gastric wall thickness, and cervical esophagus diameter had significant differences between the three groups. The EoE group had the highest mean ± SD abdominal esophageal wall thickness of 2.73 ± 0.66 mm, gastric wall thickness of 4.30 ± 0.79 mm, and cervical esophageal wall thickness of 2.32 ± 1.21 mm. The GERD group had the lowest mean ± SD cervical esophagus diameter and distensibility of the abdominal esophagus. On the other hand, this group had the highest mean distensibility of the cervical esophagus. The highest area under the curve (AUC) for discriminating EoE from controls were 0.83 and 0.80 for gastric wall thickness and abdominal esophageal wall thickness, respectively. Moreover, the highest AUCs for discriminating EoE from GERD were 0.80 and 0.71 for gastric wall thickness and cervical esophageal wall thickness, respectively. Conclusions: Although the mean of ultrasound findings in the EoE group was significantly different from the control and GERD group, the ability to discriminate EoE from the control and GERD groups was moderate (0.70
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来源期刊
CiteScore
0.90
自引率
20.00%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.
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