{"title":"生物制造的银纳米颗粒协同激活两性霉素B对抗成熟的生物膜形式","authors":"S. Halbandge, Supriya P. Mortale, S. Karuppayil","doi":"10.2174/1875933501704010001","DOIUrl":null,"url":null,"abstract":"Received: April 27, 2017 Revised: July 27, 2017 Accepted: August 10, 2017 Abstract: Background: Biofilm formation by Candida albicans is a significant clinical challenge. Fungal biofilms are resistant to most of the currently available antifungal agents. Amphotericin-B (AmB) is an antifungal agent used for the treatment of systematic fungal infections but it is well known for its toxicities and side-effects. Novel approaches are needed to treat these infections that can reduce its toxicities.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"8 1","pages":"1-16"},"PeriodicalIF":0.0000,"publicationDate":"2017-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":"{\"title\":\"Biofabricated Silver Nanoparticles Synergistically Activate Amphotericin B Against Mature Biofilm Forms of\",\"authors\":\"S. Halbandge, Supriya P. Mortale, S. Karuppayil\",\"doi\":\"10.2174/1875933501704010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Received: April 27, 2017 Revised: July 27, 2017 Accepted: August 10, 2017 Abstract: Background: Biofilm formation by Candida albicans is a significant clinical challenge. Fungal biofilms are resistant to most of the currently available antifungal agents. Amphotericin-B (AmB) is an antifungal agent used for the treatment of systematic fungal infections but it is well known for its toxicities and side-effects. Novel approaches are needed to treat these infections that can reduce its toxicities.\",\"PeriodicalId\":22993,\"journal\":{\"name\":\"The Open Nanomedicine Journal\",\"volume\":\"8 1\",\"pages\":\"1-16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Nanomedicine Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1875933501704010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Nanomedicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1875933501704010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
摘要
摘要:背景:白色念珠菌形成生物膜是一项重大的临床挑战。真菌生物膜对目前大多数可用的抗真菌药物具有耐药性。两性霉素- b (AmB)是一种用于治疗系统性真菌感染的抗真菌药物，但其毒性和副作用是众所周知的。需要新的方法来治疗这些感染，以减少其毒性。
Biofabricated Silver Nanoparticles Synergistically Activate Amphotericin B Against Mature Biofilm Forms of
Received: April 27, 2017 Revised: July 27, 2017 Accepted: August 10, 2017 Abstract: Background: Biofilm formation by Candida albicans is a significant clinical challenge. Fungal biofilms are resistant to most of the currently available antifungal agents. Amphotericin-B (AmB) is an antifungal agent used for the treatment of systematic fungal infections but it is well known for its toxicities and side-effects. Novel approaches are needed to treat these infections that can reduce its toxicities.
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