旋转血栓弹性测量法鉴别脓毒症预防性无分离肝素输注的效果

M. Nouri, Elchin Barzegar, A. Ahmadi, F. Etezadi, M. Mojtahedzadeh
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引用次数: 0

摘要

背景与目的凝血功能异常在脓毒症患者中较为常见。预防危重患者血栓形成的标准护理是每天皮下注射2或3次无分离肝素,但在某些情况下无效。我们使用旋转血栓弹性测量法研究了等量连续静脉输注对凝血特性的影响。患者随机分为皮下注射组(n = 15)和输液组(n = 15)。皮下注射组给予肝素5000单位,每日3次,静脉注射组给予肝素500单位/小时。结果输液组第2、7天凝血时间明显低于皮下组(P < 0.05)。输液组在第2天、第7天的凝块形成时间也显著低于对照组(P < 0.05)。结论静脉滴注低剂量肝素可有效预防脓毒症患者血栓形成。这种方法可用于血栓形成风险较高的人群。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differentiating the Effects of Prophylactic Unfractionated Heparin Infusion by Rotational Thromboelastometry in Sepsis
Background and Aims Coagulation abnormalities are relatively common among septic patients. The standard of care for preventing thrombosis in critically ill patients is subcutaneous administration of unfractionated heparin 2 or 3 times a day, which fails in some cases. We studied the influence of continuous intravenous infusion of equivalent doses on coagulation profile using rotational thromboelastometry. Subjects and Methods Patients were randomly allocated to the subcutaneous group (n = 15) or infusion group (n = 15). The subcutaneous group received 5000 units 3 times a day, whereas the infusion group received heparin 500 units/hour intravenously. Results Clotting times were significantly lower in the infusion group compared with the subcutaneous group on days 2 and 7 (P < 0.05). Clot formation times were also significantly lower in the infusion group both on days 2 and 7 (P < 0.05). Conclusions Intravenous infusion of low-dose heparin might provide more efficient thromboprophylaxis in septic patients. This method could be used in those who are at higher risk of thrombosis.
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