甲基化标记在头颈部鳞状细胞癌中的稳定性

Head & neck surgery Pub Date : 2016-04-01 DOI:10.1002/hed.24223

Shama Virani, E. Light, Lisa A. Peterson, M. Sartor, Jeremy M G Taylor, J. Mchugh, G. Wolf, L. Rozek

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引用次数: 7

摘要

随着癌症的进展，甲基化模式改变以促进致瘤表型。然而，甲基化标记物随时间的稳定性以及活检样本代表较大肿瘤样本的程度尚不清楚。这一信息对此类生物标志物的临床应用至关重要。

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Stability of methylation markers in head and neck squamous cell carcinoma

As cancer progresses, methylation patterns change to promote the tumorigenic phenotype. However, stability of methylation markers over time and the extent that biopsy samples are representative of larger tumor specimens are unknown. This information is critical for clinical use of such biomarkers.

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Head & neck surgery

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