与重症COVID-19患者死亡或生存相关的临床、生化和ATR-FTIR光谱参数

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-11 DOI:10.1155/2023/3423183

A. Martínez-Cuazitl, M. M. Mata-Miranda, Miguel Sanchez-Brito, Daniel Valencia-Trujillo, Amanda M. Avila-Trejo, R. Delgado-Macuil, Consuelo Atriano-Colorado, Francisco Garibay-Gonzalez, V. Sánchez-Monroy, G. J. Vázquez-Zapién

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引用次数: 3

摘要

2019冠状病毒病(COVID-19)的症状范围广泛，使用单一参数预测疾病演变具有挑战性。因此，为了描述重症COVID-19住院患者对SARS-CoV-2感染的病理生理反应，我们根据生存或死亡、社会人口学和临床特征、唾液样本的生化和免疫衰减全反射-傅里叶变换红外(ATR-FTIR)光谱及其与化学计量学结果的相关性进行了比较。在此，我们证明了ATR-FTIR光谱允许描述与细胞损伤相关的事件，如脂质生物发生和与乳酸脱氢酶和白蛋白水平相关的蛋白质的二级结构。此外，死于COVID-19的患者的体液(IgM)和细胞(IFN-γ、TNF-α、IL-10和IL-6)反应也有所增加。

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Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19

The wide range of symptoms of the coronavirus disease 2019 (COVID-19) makes it challenging to predict the disease evolution using a single parameter. Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to survival or death, the sociodemographic and clinical characteristics, the biochemical and immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples and their correlation with chemometric findings. Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. Moreover, humoral (IgM) and cellular (IFN-γ, TNF-α, IL-10, and IL-6) responses were also increased in patients who died from COVID-19.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.